A salt or ester of α-ketoglutaric acid.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress.
Huang et al., "Alpha-ketoglutarate suppresses the NF-KB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway," Oncotarget, vol.
Our patient with hyperglycemia and dysmorphic features had a deletion of 7.23 Mb comprising the region 7p13-p12.1, with involvement of 39 Online Mendelian Inheritance in Man genes, including glucokinase associated with maturity-onset diabetes of the young, CCM2 associated with type 2 cerebral cavernous malformations, insulin-like growth factors binding protein-3 associated with decreased postnatal growth, and oxoglutarate dehydrogenase associated with alpha-ketoglutarate dehydrogenase deficiency (short stature, hypotonia, cognitive impairment, and movement abnormalities).
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
[sup][21] demonstrated that the ketogenic diet and Deanna Protocol (a diet consisting of 10% arginine alpha-ketoglutarate, 1.0% gamma aminobutyric acid, 0.1% ubiquinol, 10% medium-chain triglyceride)-fed mice had a significantly longer survival time than the standard diet-fed mice.
Many studies report on the antioxidant properties of alpha-ketoglutarate (AKG) which is an important intermediate in the Krebs cycle.
Alpha-ketoglutarate (AKG), an anion of alpha-ketoglutaric acid, is an important intermediate in the Krebs cycle, which couples amino acid metabolism with glucose oxidation.
BCAA-derived carbons can then be fed into the citric acid cycle to form alpha-ketoglutarate, and then the alpha-ketoglutarate can be transaminated to glutamate to maintain glutamate levels.
Glutamate dehydrogenation produces alpha-ketoglutarate to replenish the tricarboxylic acid cycle intermediates.
Using GC-MS (Gas chromatography-mass spectrometry) to detect alpha-hydroxyisovalerate, lactate, pyruvate and alpha-ketoglutarate. Random urine sample is usually sufficient.