cyclodextrin

(redirected from Alpha-cyclodextrins)
Also found in: Dictionary, Encyclopedia.

cyclodextrin

(sī-klō-dĕks′trĭn)
A molecule made of linked dextrose subunits that can be used in drug delivery in the body. Cyclodextrins have lipid centers surrounded by water-soluble exteriors. This combination allows fat-soluble medicines to be carried through the bloodstream to lipid-rich organs like the brain.
References in periodicals archive ?
For 30 days before the beginning of the supplement period, participants in both groups gained an average of 2.2 pounds each, but once the supplement period began, placebo recipients continued to gain weight, while subjects in the alpha-cyclodextrin group had no significant further weight gain.
(10) In addition, patients taking alpha-cyclodextrin had an increase in levels of adiponectin, a hormone that appears to be protective against atherosclerosis, while levels of this beneficial substance fell in the placebo group.
In an attempt to acutely lower post-meal triglycerides, researchers randomly assigned healthy adults to receive either 2 grams alpha-cyclodextrin or a placebo immediately following a commercially prepared high-fat breakfast rich in saturated fat.
Alpha-cyclodextrin's effects can be sustained over long periods of time, according to a study of 66 obese diabetic patients.
But a recent study showed that alpha-cyclodextrin has benefits on body weight and lipid profiles even in healthy, non-obese, nondiabetic people, demonstrating genuine preventive effects.
A group of overweight people (with a body mass index of 25 to 30) were randomly assigned a placebo or 2 grams alpha-cyclodextrin with each meal (6 grams/ day).
(17) After an overnight fast, subjects consumed either 100 grams (about 3.3 ounces) of white bread with water or 100 grams of white bread with 10 grams alpha-cyclodextrin in water.
(18) It also shows that you can gain control not only of your blood lipids and body weight, but also metabolic and cardiovascular risks, by taking alpha-cyclodextrin before meals.
Similar results were obtained in a study in which the alpha-cyclodextrin (at doses of 2, 5, and 10 grams) was directly mixed with boiled white rice.
A new form of fiber, alpha-cyclodextrin, selectively engulfs dietary fat from the intestine, holding about 9 grams of fat for each gram of the supplement ingested.
And just as importantly, alpha-cyclodextrin, dosed at about 6 grams/day, can reduce high levels of triglyceride, cholesterol, and pro-atherosclerosis lipidcarrying proteins like ApoB, the latter of which is known to be increased by dietary saturated fat.
Studies show that regular use of alpha-cyclodextrin slows weight gain in both obese and non-obese patients, and those both with and without type II diabetes.