ADRA2A

(redirected from Alpha-2A adrenoceptor)

ADRA2A

A gene on chromosome 10q24-q26 that encodes alpha-2A-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which plays a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the CNS, smooth muscle contraction and thermoregulation.
 
ADRA2A agonists
Oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine.
 
ADRA2A antagonists
Yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
Mentioned in ?
References in periodicals archive ?
Antinociceptive response to an exogenous alpha-2 agonist is mediated by an alpha-2A adrenoceptor (20).
Administration of dexmedetomidine in mice lacking both alpha-2A and alpha-2B receptors, failed to produce the initial hypertension, which can be attributed to the alpha-2B adrenoceptor subtype (33) and the central hypotensive effect related to the alpha-2A adrenoceptor subtype (30).