Alpha-2 agonist

Alpha-2 agonist (alpha-2 adrenergic receptor agonist)

A class of drugs that bind to and stimulate alpha-2 adrenergic receptors, causing responses similar to those of adrenaline and noradrenaline. They inhibit aqueous humor production and a have a wide variety of effects, including dry mouth, fatigue, and drowsiness.
Mentioned in: Glaucoma
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References in periodicals archive ?
Clonidine, an alpha-2 agonist induces dose dependent anti-nociception mainly through stimulation of alpha-2 adrenoceptors in dorsal horn mimicking activation of descending inhibitory pathways.
EVALUATION OF THE EFFECT OF MAGNESIUM SULPHATE VS. CLONIDINE AS AN ADJUVANT TO EPIDURAL LEVOBUPIVACAINE IN PATIENTS UNDERGOING LOWER ABDOMINAL SURGERIES--A PROSPECTIVE, RANDOMISED AND DOUBLE-BLINDED STUDY
At present, clonidine and dexmedetomidine are the two alpha-2 agonist commonly used in clinical practice.
Comparative evaluation of different doses of intravenous dexmedetomidine during laparoscopic cholecystectomy under general anesthesia
Non availability of u-receptor opioids forces the anesthetists working in some parts of the world to use substitutes like nalbuphine; which is a k-receptor agonist and antagonist at u-opioid1; or tramadol, which acts as a weak u agonist with additional alpha-2 agonist activity and weak inhibitor of norepinephrine and serotonin reuptake2.
A COMPARISON OF EQUIPOTENT DOSES OF TRAMADOL AND NALBUPHINE IN GYNECOLOGICAL LAPAROTOMIES POSTOPERATIVELY
Xylazine, an dose alpha-2 agonist, produces a dose-related degree of sedation and its intravenous injection results in deeper sedation than intramuscular administration (Clarke et al.
Diagnosis and Retrieval of Pharyngeal Foreign Body in Cattle
3,4) If concerned, however, alternative ADHD treatment such as alpha-2 agonist treatment could be considered.
New onset of tics
In spite of its popularity in the western countries as an alternative therapy for the menopausal vasomotor problems, centrally active alpha-2 agonist clonidine is only marginally more effective than placebo, but considerably less efficient than estrogen [5].
Alternatives of menopausal hormone therapy/Alternative hormonske terapije u menopauzi
Injectable drug company Hospira Inc (NYSE:HSP) revealed on Monday that the US Food and Drug Administration (FDA) has awarded pediatric exclusivity for its alpha-2 agonist Precedex (dexmedetomidine HCl) injection.
Hospira Inc gets US FDA's six months pediatric exclusivity for Precedex injection
Antinociceptive response to an exogenous alpha-2 agonist is mediated by an alpha-2A adrenoceptor (20).
Alpha-2B adrenergic receptor mediated hemodynamic profile of etomidate
23) The combination of an alpha-2 agonist and local anesthetic agent was also shown to produce longer-lasting analgesia.
A multimodal approach to management of suspected neuropathic pain in a prairie falcon (Falco mexicanus)
The alpha-2 agonist clonidine (6) may be used to relieve adrenergic withdrawal symptoms.
Medical treatment of opioid dependence within the South African context
However, due to severe side effects like muscle rigidity, frequent convulsions, and rough recoveries, these agents should only be used in combination with an alpha-2 agonist or another tranquilizing or sedative drug (Kreeger et al.
Chemical immobilization of free-ranging moose
ALPHAGAN(tm) is a selective alpha-2 agonist which significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters.
Allergan's ALPHAGAN receives marketing approval for treatment of glaucoma

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