Alpha-2 agonist

Alpha-2 agonist (alpha-2 adrenergic receptor agonist)

A class of drugs that bind to and stimulate alpha-2 adrenergic receptors, causing responses similar to those of adrenaline and noradrenaline. They inhibit aqueous humor production and a have a wide variety of effects, including dry mouth, fatigue, and drowsiness.
Mentioned in: Glaucoma
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
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Dexmedetomidine is an alpha-2 agonist gaining popularity in neurosurgery due to its unique properties as a sedative, anxiolytic and anaesthetic sparing effects without respiratory depression.
Dexmedetomidine is an alpha-2 agonist that can provide sedative and analgesic effects.
Dexmedetomidine is a highly selective and potent alpha-2 agonist (alpha 2:alpha 1 = 1620:1) and is 7-10 times more specific for alpha-2 receptors compared to clonidine and has a shorter duration of action.
DEX, an alpha-2 agonist, is a widely used sedative in intensive care units.
Non availability of u-receptor opioids forces the anesthetists working in some parts of the world to use substitutes like nalbuphine; which is a k-receptor agonist and antagonist at u-opioid1; or tramadol, which acts as a weak u agonist with additional alpha-2 agonist activity and weak inhibitor of norepinephrine and serotonin reuptake2.
Xylazine, an dose alpha-2 agonist, produces a dose-related degree of sedation and its intravenous injection results in deeper sedation than intramuscular administration (Clarke et al., 2014).
In spite of its popularity in the western countries as an alternative therapy for the menopausal vasomotor problems, centrally active alpha-2 agonist clonidine is only marginally more effective than placebo, but considerably less efficient than estrogen [5].
Injectable drug company Hospira Inc (NYSE:HSP) revealed on Monday that the US Food and Drug Administration (FDA) has awarded pediatric exclusivity for its alpha-2 agonist Precedex (dexmedetomidine HCl) injection.
Clonidine is an alpha-2 agonist; "agonist" is the opposite of ' "antagonist," meaning it mimics or increases the effects.
Other authors have also described this biphasic response to the intravenous response of an alpha-2 agonist (22).

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