Alpha-1-antitrypsin


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SERPINA1

A gene on chromosome 14q32.1 that encodes a member of the serine protease inhibitor (serpin) family, whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin and plasminogen activator, the latter three of which it irreversibly inhibits. 

Molecular pathology
SERPINA1 mutations cause pulmonary emphysema and liver disease.

Alpha-1-antitrypsin (AAT)

A blood component that breaks down infection-fighting enzymes such as elastase.
References in periodicals archive ?
Alpha-1-antitrypsin deficiency: smoking, decline in lung function and implications for therapeutic trials.
The electrophoretic alpha-1-globin pattern of serum alpha-1-antitrypsin deficiency.
American Thoracic Society/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-1-antitrypsin deficiency.
Liver injury in alpha-1-antitrypsin deficiency: an aggregated protein induced mitochondrial injury.
For many people with rare illnesses such as lysosomal storage disease, hemophilia, Guillain-Barre syndrome, and Alpha-1-antitrypsin deficiency disease, specialty pharmaceuticals represent their standard of care, keeping symptoms stable and helping to reclaim quality of life.
The cartridges use affinity-purified polyclonal antibodies to remove more than 98 percent of the six most abundant proteins (albumin, immunoglobulin G, immunoglobulin A, alpha-1-antitrypsin, transferrin and haptoglobin) in human serum and the three most abundant proteins (albumin, immunoglobulin G and transferrin) in mouse serum, with minimal non-specific removal of other proteins.
As published in the March issue of Cell Transplantation, Geron scientists describe protocols that differentiate hESCs into human hepatocytes that express albumin, alpha-1-antitrypsin, glycogen and toxicity studies to be performed earlier in the drug discovery process, enabling the elimination of toxic compounds before undertaking costly human trials.
a private biotechnology company focused on the development of recombinant alpha-1-antitrypsin.
Today the University of Colorado Health Science Center (UC) announced that it had demonstrated in laboratory studies a potentially effective treatment against the AIDS virus using a natural substance called alpha-1-antitrypsin (AAT) which is a naturally occurring component in human blood.

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