SERPINA3

(redirected from Alpha-1-Antichymotrypsin)
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SERPINA3

A gene on chromosome 14q32.1 that encodes a member of the serine protease inhibitor (serpin) family, which is a plasma protease inhibitor.

Molecular pathology
Variations in SERPINA3’s sequence have been implicated in Alzheimer's disease; SERPINA3 deficiency has been linked to liver disease. SERPINA3 mutations have been found in patients with Parkinson disease and COPD.
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References in periodicals archive ?
Serum prostate-specific antigen complexed to alpha-1-antichymotrypsin as an indicator of prostate cancer.
One possible consequence of aberrant proteolytic processing of APP could be the release of alpha-1-antichymotrypsin (ACT), a powerful inhibitor of trypsin and chymotrypsin(15).
PSA is exposed to several major extracellular protease inhibitors, (15) most importantly, alpha-1-antichymotrypsin (ACT), (16, 17) alpha-l-protease inhibitor (API), (18) protein C inhibitor (PCI), (19) alpha-2-macroglobulin (AMG), (20) and pregnancy zone protein (PZP).

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