SERPINA1

(redirected from Alpha-1 protease inhibitor)

SERPINA1

A gene on chromosome 14q32.1 that encodes a member of the serine protease inhibitor (serpin) family, whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin and plasminogen activator, the latter three of which it irreversibly inhibits. 

Molecular pathology
SERPINA1 mutations cause pulmonary emphysema and liver disease.
Mentioned in ?
References in periodicals archive ?
Key words: alpha-1 antitrypsin deficiency, alpha-1 protease, alpha-1 protease inhibitor, genetic epidemiology, Pi phenotypes, Pi subtypes, population genetics.

Full browser ?