SERPINA1

(redirected from Alpha-1 protease inhibitor)

SERPINA1

A gene on chromosome 14q32.1 that encodes a member of the serine protease inhibitor (serpin) family, whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin and plasminogen activator, the latter three of which it irreversibly inhibits. 

Molecular pathology
SERPINA1 mutations cause pulmonary emphysema and liver disease.
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Before Amgen, Haeberle was senior manager, clinical development at Baxter Healthcare Corporation, where he led post-approval clinical activities for Baxter's Alpha-1 Protease Inhibitor franchise, encompassing the brands Aralast and Glassia, used in the treatment of lung disease.
Key words: alpha-1 antitrypsin deficiency, alpha-1 protease, alpha-1 protease inhibitor, genetic epidemiology, Pi phenotypes, Pi subtypes, population genetics.

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