alpha-synuclein

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Related to Alpha synuclein: Lewy bodies

alpha-synuclein

(ăl′fə-sĭ-no͞o′klē-ĭn, -nyo͞o′-)
n.
A polypeptide protein found primarily in brain neurons but seen also in the fibrils in Parkinson's disease, in the amyloid plaques of Alzheimer's disease, and in brain tissue affected by other neurodegenerative diseases.

SNCA

A gene on chromosome 4q21 that encodes alpha synuclein, which may be involved in regulating dopamine release and transport. SNCA induces fibrillisation of microtubule-associated protein tau, reduces neuronal responsiveness to apoptotic stimuli, and downregulates caspase-3.
References in periodicals archive ?
When someone has a GBA1 mutation, protein recycling does not work properly in the cell, creating a build-up of alpha synuclein, which is released into the brain, contributing to the spread of Parkinson's.
The findings demonstrated that patients with early stage Parkinson's disease had lower levels of amyloid beta and alpha synuclein.
Moussa is planning a phase II clinical trial in participants who have been diagnosed with disorders that feature build-up of alpha Synuclein, including Lewy body dementia, Parkinson's disease, progressive supranuclear palsy (PSP) and multiple system atrophy (MSA).
Standaert will work to evaluate the clinical utility and benefit of TorsinA in protecting brain neurons against certain misfolded proteins, like alpha synuclein, which cause PD in mammalian models.
By normalizing brain levels of alpha synuclein, beta amyloid and tau, it provides an avenue to treat Alzheimer's and Parkinson's disease early so as to prevent the onset or diminish the severity of cognitive decline.