alpha-synuclein

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Related to Alpha synuclein: Lewy bodies

alpha-synuclein

(ăl′fə-sĭ-no͞o′klē-ĭn, -nyo͞o′-)
n.
A polypeptide protein found primarily in brain neurons but seen also in the fibrils in Parkinson's disease, in the amyloid plaques of Alzheimer's disease, and in brain tissue affected by other neurodegenerative diseases.

SNCA

A gene on chromosome 4q21 that encodes alpha synuclein, which may be involved in regulating dopamine release and transport. SNCA induces fibrillisation of microtubule-associated protein tau, reduces neuronal responsiveness to apoptotic stimuli, and downregulates caspase-3.
References in periodicals archive ?
Cooper, "Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: Relevance to Parkinson's disease pathogenesis," Journal of Neurochemistry, vol.
Kordower et al., "Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat," Neurobiology of Disease, vol.
Ruf et al., "Exosomal cell-to-cell transmission of alpha synuclein oligomers," Molecular Neurodegeneration, vol.
The work is the first to link the release of alpha synuclein, a naturally-occurring protein that plays a central role in the development of Parkinson's, with its most common genetic risk factor--GBA-1--shedding new light on its role in the progression of the devastating neurological condition and its symptoms.
Those protein biomarkers include amyloid beta, total tau, phosphorylated tau, alpha synuclein and the ratio of total tau to amyloid beta.
"It gets rid of alpha synuclein and tau in a number of movement disorders, such as Parkinson's disease as well as Lewy body dementia."
Parkinson's disease (PD), a neurodegenerative disorder, is characterized by the selective degeneration of the nigrostriatal dopaminergic neurons, continuing or permanent deficiency of dopamine, accretion of an abnormal form of alpha synuclein in the adjacent neurons, and dysregulation of ubiquitin proteasomal system, mitochondrial metabolism, permeability and integrity, and cellular apoptosis resulting in rigidity, bradykinesia, resting tremor, and postural instability.