alpha 1-antitrypsin deficiency

(redirected from Alpha one)

alpha 1-antitrypsin deficiency

A disorder caused most frequently by a mutation in the SERPINA 1 gene, causing the Z-allele with a substitution of lysine for glutamic acid at position 342. Alpha 1-antitrypsin is mainly produced in the liver and is protective against the proteolytic enzyme neutrophil elastase that can damage the air sacs in the lungs and the cells of the liver. People with alpha 1-antitrypsin deficiency are more prone than normal to EMPHYSEMA and to certain forms of liver disease. It is responsible for 25 per cent of deaths from juvenile liver cirrhosis. A strong case has been made that this was the disease from which the composer Frédéric Chopin died.
References in periodicals archive ?
Javi gets to fulfill his action star dreams further by leading "Kid Alpha One," a hardcore action film.
McGillis, who was diagnosed with alpha one antitrypsin, a lung condition, five years ago, said that she is a homebody.
Alpha One Sixteen: A Combat Infantryman's Year in Vietnam
Vahana's Alpha One, the first full-scale aircraft, lifted off on January 31, 2018 in Pendleton, Oregon, the company said.
Now, the aerospace giant has proven that it wasn't joking: Airbus' Vahana team have successfully flown their autonomous air taxi dubbed 'Alpha One' for the first time.
Jeffrey Kellar, Alpha's president and CEO, said, "The acquisition more than doubles our production capacity on the continent, making Alpha one of the largest single stage blow-molding operations in Europe."
Yesterday, speaking on behalf of Alpha One Foundation, chief executive Kitty O'Connor stated that the patients would be "completely devastated" and "fearful for the future of their health".
Yahlive has partnered with Adriatic Tours S.L., owners of Alpha One RTV Network, to add Face TV to its European channel bouquet.
"I decided to upload the footage monthly to my dedicated facebook page Alpha One Zero Alpha.
This relationship, experience, and result, in my opinion, make Tri Alpha one of the best cases from the annals of venture investing.
Off the runway, I'll turn left on Alpha and taxi to the ramp using Alpha One. Transient tie-down is in front of the terminal, by the fuel pumps."
This means that the public is still going by rumours of specs revealed before, including the 4.7-inch Super AMOLED display, the Android 4.4 Ktikat OS, an octa-core Exynos processor, 12-megapixel rear camera, fingerprint and heart rate sensor and the much-awaited metallic frame to make the Samsung Galaxy Alpha one of the more premium handsets of the South Korean company to date.