In alpha thalassemia
, alpha globin expression is deficient and there is a corresponding excess of beta globin chains.
Results: Co-inheritance of alpha thalassemia
(-a3.7, -a4.2) with homozygous beta thalassemia was detected in 30% cases of studied cohort (37 out of 121).
In the mid-western region, the migratory target home of Brazilians from several regions of the country, a sample of 404 individuals from 55 cities in the state of Goias revealed a 10.1% prevalence of hereditary anemia, thalassemia and hemoglobin variants, specifically 5.2% of heterozygous alpha thalassemia
, 2.2% of hemoglobin S heterozygosity (HbAS); 1% heterozygosity for hemoglobin C (HbAC); 0.7% of lower beta thalassemia; 0.5% alpha-thalassemia and heterozygous for HbS; 0.3% alpha-thalassemia and heterozygous for HbC; and 0.3% heterozygous for hemoglobin D (HbAD) (MELO-REIS et al., 2006).
frequency of alpha thalassemia
in Pakistani population as screened through cation exchange chromatography.
A 49-year-old African-American male with a past medical history of the alpha thalassemia
trait who had a three-year history of marginal zone monocytoid B-cell non-Hodgkin lymphoma (NHL), which was diagnosed on a lymph node and bone marrow biopsies, had a longstanding splenomegaly with symptoms of fever, night sweats, fatigue, weight loss, mild abdominal pain, and early satiety.
major--new mutations, intrauterine management, and outcomes.
is a reduction or absence of alpha chains ..
We report of an Iranian family with history of a rare haemoglobin variant, Haemoglobin J associated with alpha thalassemia
, discovered while performing premarital thalassemia screening.
The prevalence of sickle cell anemia, beta-thalassemia major, beta thalassemia, alpha thalassemia
, alpha thalassemia
trait was found 0.35% (n=631), 0.07% (n=132), 0.06 % (n=118), 0.005% (n=9), 0.08% (n=150), respectively.
It is estimated, however, that 15% of African Americans (the US population with the highest incidence of any form of thalassemia) are affected by alpha thalassemia
. (14) The incidence of beta thalassemia among Mediterranean, African, and Middle Eastern populations ranges from about 5% to 25%.
* Alpha thalassemia
occurs when a gene or genes related to the alpha globin protein are missing or changed (mutated).
Neither Hb Rambam (also known as Hb J-Cambridge) a Gly69Asp substitution (28), nor Hb Kenitra, a beta 69 Gly>Arg change associated with an alpha thalassemia
show abnormal hematological parameters attributed to the [beta]69 substitution (29).