alpha-2 macroglobulin

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alpha-2 macroglobulin

Plasma glycoprotein made principally by the liver that inhibits serine proteases, leukocyte elastase, and proteinase 3, but not matrix metalloproteinases.
See also: macroglobulin
References in periodicals archive ?
Strickland, "The human alpha 2-macroglobulin receptor: identification of a 420-kD cell surface glycoprotein specific for the activated conformation of alpha 2-macroglobulin," Journal of Cell Biology, vol.
Fenofibrate treatment also reduced plasma concentrations of the acute phase proteins fibrinogen, C-reactive protein, serum amyloid A, plasminogen, and alpha 2-macroglobulin in human subjects [49-51].
The value of various parameters " C-reactive protein (CRP), white blood cell (WBC) count, lymphocyte/leucocyte ratio, interleukin-6 (IL-6), IL-10, IL-4, IL-5, IL-12, tumour necrosis factor alpha ( TNF), endotoxin, erythrocyte sedimentation rate (ESR), procalcitonin, fibrinogen, alpha 2-macroglobulin, alpha 1- antitrypsin, D-lactate " for diagnosis of AA have been studied.4 However, they have proved non-superior to clinical history, physical examination, and usual laboratory studies in diagnosing AA at an early stage.5
Characterization of novel monoclonal antibodies for prostate-specific antigen (PSA) with potency to recognize PSA bound to alpha 2-macroglobulin. Clinical Chem 2005;51(1):84-92.
Molecular cloning and expression analysis of alpha 2-macroglobulin in the kuruma shrimp Marsupenaeus japonicus.
The binding and removal of excessive cytokines is mediated by [alpha]-2-macroglobulin (alpha 2-macroglobulin), a naturally occurring high-molecular-weight plasma glycoprotein.
The structure around the thioester bond in bovine alpha 2-macroglobulin: possible implications for the conformational stability of the inhibitor on thioester cleavage.
Borth in 1992 [22] studied the alpha 2-macroglobulin ([alpha]2-M) which is an inhibitor for the proteinase enzyme in the blood and tissue.
Alpha 2-macroglobulin, a multifunctional binding protein with targeting characteristics.