antiplasmin

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antiplasmin

 [an″te-, an″ti-plaz´min]
a substance in the blood that inhibits plasmin. The most important is α2-antiplasmin, which acts by forming stable complexes with free plasmin. It is also crosslinked to fibrin by coagulation factor XIII and inhibits the binding of plasminogen to fibrin. Inherited deficiency of α2-antiplasmin results in tendency to severe bleeding, including extravasation into joints or their synovial cavities.

an·ti·plas·min

(an'tē-plaz'min),
A substance that inhibits or prevents the effects of plasmin; found in plasma and some tissues, especially the spleen and liver.
Synonym(s): antifibrinolysin

an·ti·plas·min

(an'tē-plaz'min)
A substance that inhibits or prevents the effects of plasmin; found in plasma and some tissues, especially the spleen and liver.
Synonym(s): antifibrinolysin.
References in periodicals archive ?
Laboratory findings Lab test Patient's value Normal values Hemoglobin (g/dL) 8.3 13.5-17.5 Platelet count ([10.sup.9]/L) 165,000 150-450,000 Reticulocyte count 4.5% 0.4%-2.4% Prothrombin time (seconds) 13 11-14 Partial thromboplastin time (seconds) 30 20-39 Alpha 2-antiplasmin levels 153% 85%-156% Euglobulin lysis time (minutes) >60 90-240 Platelet function analysis Collagen ADP (seconds) 81 55-137 Collagen epinephrine (seconds) 123 78-199
Protease inhibitors include alpha 2-antiplasmin, plasminogen activator inhibitor-1 and alpha 1-antitrypsin.
Alpha 2-antiplasmin deficiency is inherited as a rare autosomal recessive disorder.
Collen, "Primary structure of human alpha 2-antiplasmin, a serine protease inhibitor (serpin)," Journal of Biological Chemistry, vol.
Haber, "Platelet factor XIII increases the fibrinolytic resistance of platelet-rich clots by accelerating the crosslinking of alpha 2-antiplasmin to fibrin," Thrombosis and Haemostasis, vol.