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Member of a class of antifungal agents that works by inhibiting squalene epoxidase, an enzyme involved in the synthesis of ergosterol, a component of fungal cell walls.
Farlex Partner Medical Dictionary © Farlex 2012
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(12-14) It is a member of a new class of antifungal agents, the allylamines, which have a different mechanism of action (squalene epoxidase inhibitor) than the azoles have.
Terbinafine, in the allylamine class, also inhibits ergosterol biosynthesis, but at a different point in the pathway.
Naftifine is an allylamine drug, and is mainly an antidermatophyte agent --albeit a "very, very potent antidermatophyte" --with no antibacterial activity, she said.
Piras, "Antiproliferative synergism of the allylamine SF 86327 and ketoconazole on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi" Antimicrobial Agents and Chemotherapy, vol.
Tinea corporis on a non-hair-bearing area is readily cleared with a topical azole antifungal agent, such as ketoconazole cream 2% twice daily for 2 weeks or a topical allylamine, such as terbinafine cream 1%, twice daily for 2 weeks.
His team also developed an intumescent nanocoating formed by the layer-by-layer assembly of thin films of poly(sodium phosphate) and poly(allylamine) that was effective for protecting cotton fabric when 20 full layers were applied to each individual fiber.
Terbinafine hydrochloride, a potent antifungal agent from allylamine antifungals, was selected as a model drug because it is very effective in treatment of dermatophyte infections and is a drug of choice for treatment of onychomycosis.
As depicted in Scheme 2, condensation of allylamine with glyceraldehyde 5 gave imine 6, which was then further converted to secondary amine 7 by zinc mediated Barbier allylation [13, 27-32] protocol with good diastereoselectivity (anti/syn = 9: 1) in 80% yield.
For this reason, aminolysis reactions of waste PET have been carried out using different amines such as allylamine, morpholine, hydrazine benzylamine, ethylenediamine, hexamethylenediamine, piperidine, aniline, and polyamines (25), (26).
AR coatings on glass substrates were prepared by the LBL deposition of poly(allylamine hydrochloride)/poly(acrylic acid) (PAH/PA A) polyelectrolyte, which has been described in detail elsewhere.
Poly(allylamine hydrochloride) (PAH) (MW ~15,000) was purchased from Sigma-Aldrich.