alloxan


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Related to alloxan: streptozotocin

al·lox·an

(ă-loks'-an),
An oxidation product of uric acid, 2,4,5,6-pyrimidinetetrone; administration to experimental animals causes hypoglycemia resulting from insulin liberation, followed by hyperglycemia resulting from destruction of the islets of Langerhans (alloxan diabetes).

alloxan

/al·lox·an/ (ah-lok´san) an oxidized product of uric acid that tends to destroy the islet cells of the pancreas, thus producing diabetes (alloxan diabetes).

alloxan

[əlok′san]
an oxidation product of uric acid that is found in the human intestine in diarrhea. Alloxan has been used to produce diabetes in experimental animals by destroying the insulin-secreting islet cells of the pancreas.

alloxan

An oxygenated pyrimidine derivative, which is a toxic glucose analogue that induces experimental diabetes by selectively destroying pancreatic beta cells by superoxide production.

al·lox·an

(AX) (ă-loks'an)
An oxidation product of uric acid.

alloxan (əlok´san),

n a substance, mesoxalyl urea, capable of producing experimental diabetes by destroying the islet cells of the pancreas.

alloxan

an oxidized product of uric acid which destroys β cells of the islets of Langerhans in the pancreas. It has been used in experimental studies of diabetes mellitus and in the treatment of insulinomas in dogs.
References in periodicals archive ?
Effect of diethyl dithiocarbamate on diabetogenic action of alloxan in rats.
2006, "Effect of Terminalia arjuna stem bark on antioxidant status in liver and kidney of alloxan diabetic rats," Indian J Physiol Pharmacol, 50 (2), pp.
Anti-cataract activity of Pterocarpus marsupium bark and Trigonella foenum-graecum seeds extract in alloxan diabetic rats.
The hypoglycemic effect of Syzigium seed on alloxan induced diabetic rats was observed in a study (Prince et al 2004).
guajava is known to contain free sugars (9) yet the fruit juice showed hypoglycaemic effect in alloxan treated mice and diabetic volunteers (11).
Administered to alloxan induced diabetic mice in a concentration of 20 mg/kg dandelion extract significantly reduced glucose and fructosamine levels.
Antihyperglycemic effect of allyl propyl disulphide isolated from onion has previously been shown in glucose tolerance tests in alloxan diabetic rabbits (Augusti et al.
Several animal studies have shown that the leaf extracts possess hypoglycemic effects but are less effective in alloxan induced diabetes.