allosteric

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Related to Allosteric regulation: feedback inhibition, Allosteric enzyme, covalent modification

allosteric

 [al″o-ster´ik]
pertaining to an effect produced on the biological function of a protein by a compound not directly involved in that function (an allosteric effector) or to regulation of an enzyme involving cooperativity between multiple binding sites (allosteric sites).
allosteric site that subunit of an enzyme molecule which binds with a nonsubstrate molecule, inducing a change in form or shape that results in inactivation of the enzyme for its substrate.

al·lo·ste·ric

(al'ō-ster'ik),
Pertaining to or characterized by allosterism.

allosteric

(ăl′ə-stĕr′ĭk)
adj.
Of or relating to the binding of a molecule to an enzyme at a site other than the active site, resulting in modulation of the enzyme's activity as a result of a change in its shape.

al′lo·ster′i·cal·ly adv.
al·los′ter·y (ə-lŏs′tə-rē) n.

allosteric

Biochemistry
adjective
(1) Referring to allostery, see there.
(2) Referring to the alteration of a binding site on a protein, usually an enzyme, due to interaction with another molecule.
 
Molecular biology
adjective Referring to the stereospecific modification of a protein by an effector to influence other protein- or nucleic acid-binding site activity.

al·lo·ste·ric

(al'ō-ster'ik)
Pertaining to or characterized by allosterism.
References in periodicals archive ?
The new basic understanding of Abl regulation will also yield insight into similar enzymes, in which allosteric regulation controls a kinase domain.
Non-hub kinless nodes (R4) are located in turn on the interface between chains and play a key role in the concerted motion underlying the allosteric regulation of hemoglobin.
A loss of allosteric regulation on the CBS enzyme activity by AdoMet was found to increase the homocysteine level [12].
Tucek S, Dolezal V (1998) Muscarinic Acetylcholine Receptors: Basic Properties and Allosteric Regulation. J Physiol 25: 511
Our study will provide insights into the molecular mechanisms of allosteric regulation, paving the way for the rational design of allosteric modulators with therapeutic potential.