Blockade of RAGE suppresses alloimmune
reactions in vitro and delays allograft rejection in murine heart transplantation.
It is consistently reported the association between mothers' HLA homozygosis and these poor outcomes, regardless of alleles' type, or mothers' HIV-1 plasma viral load, as a result of poor alloimmune
response in children and consequent prolonged survival of HIV-infected cells.
The occurrence of catalytic antibodies has been described under various pathological conditions, including autoimmune and alloimmune
Guidelines on the investigation and management of thrombocytopenia in pregnancy and neonatal alloimmune
TIM-3 inhibits T helper type 1-mediated auto- and alloimmune
responses and promotes immunological tolerance.
Timucin Taner, M.D., Ph.D., from the Mayo Clinic in Rochester, Minn., and colleagues measured donor-specific alloresponsiveness and phenotypes of peripheral blood cells after the first year to characterize the host alloimmune
response in 28 patients who underwent simultaneous liver-kidney transplantation.
response after additional red blood cell antigen challenge in immunized hematooncology patients.
The innate immune system is the critical component involved in the early stage of the allogeneic response, in which chemokines and CAMs play crucial roles not only in mediating leukocyte exodus into the graft but also in expediting dendritic cell and T-cell trafficking between the lymph nodes and the transplant, this outcome in a particular and obtained alloimmune
response mediated by T-cells .
Even though the pathogenesis of BOOP after HSCT is not clearly understood, published reports have postulated that alloimmune
injury is the primary triggering factor for its development.
Graft-versus-host disease (GVHD) is a systemic autoimmune and alloimmune
disease that is one of the most common and troublesome adverse events of allogeneic hematopoietic stem cell transplant.
The three fundamental factors that contribute to corneal allograft survival are (1) blocking the induction of the immune response against allograft antigens, (2) generation of Tregs that can suppress the destructive alloimmune
reaction, and (3) induction of apoptosis of inflammatory cells at the graft/host interface .
Chock et al., "The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune
responses in vivo," The Journal of Immunology, vol.