tretinoin

(redirected from All-trans retinoic acid)
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Related to All-trans retinoic acid: Cis-retinoic acid

tretinoin

 [tret´ĭ-no″in]
the all-trans stereoisomer of retinoic acid, used topically for treatment of cases of acne vulgaris in which comedones, pustules, and papules predominate; it prevents comedo formation and suppresses keratin synthesis; common adverse effects are erythema and desquamation. It is also administered orally in treatment of acute promyelocytic leukemia.

tret·i·no·in

(tret'i-nō'in),
A keratolytic agent. See: retinoic acid.

tretinoin

/tret·i·noin/ (tret´ĭ-noin″) the all-trans stereoisomer of retinoic acid, used as a topical keratolytic in the treatment of acne vulgaris and disorders of keratinization and administered orally in the treatment of acute promyelocytic leukemia.

tretinoin

(trĕt′ĭ-noin′)
n.
An isomer of retinoic acid used topically to treat acne and to mitigate fine facial wrinkling and orally to treat one form of leukemia.

tretinoin

[tret′inō′in]
a retinoic acid derivative.
indications It is prescribed in the topical treatment of acne vulgaris and fine wrinkles and is administered orally for inducing remission in acute promyelocytic leukemia.
contraindications Known hypersensitivity to this drug or pregnancy prohibits its use.
adverse effects Among the more serious adverse effects of topical administration are photosensitivity and red, edematous, blistered, or crusted skin. Almost everybody taking the drug orally experiences some degree of weakness, fatigue, headache, and fever, but adverse effects are seldom reasons for discontinuing use of the drug.

tretinoin

A synthetic form of vitamin A used to treat acne, keratinisation (e.g., keratosis pilaris) and dermatitis. It also stimulates the immune system and is used to treat acute promyelocytic leukaemia. Retinoic acid is the naturally occurring form of the fat-soluble vitamin A, which is critical for the transportation of monosaccharides in glycoprotein synthesis, as occurs in the turnover of mucosal epithelia of the oral cavity and the respiratory and urinary tracts.

Toxicity
Skin blistering, crusting, headache, nausea, vomiting, vertigo.

tretinoin

all-trans-retinoic acid Dermatology A synthetic derivative of vitamin A used topically to reverse some of the effects of photoaging, both clinically–↓ skin wrinkling, improved skin texture and color and microscopically–↑ epidermal thickness, ↑ collagen and dermal vessels and 'erasing' epithelial atypia and dysplasia; tretinoin restores production of collagen I in photodamaged skin and lightens postinflammatory hyperpigmentation, it is also used for acne, keratinization, dermatitis, as a cancer preventive agent, and to induce terminal differentiation of acute promyelocytic leukemia, driving it into a mature nonproliferative state of remission Mechanism Unknown, possibly related to tretinoin's inhibition of collagenase, which degrades anchoring fibril collagen; tretinoin doubles the number of anchoring fibrils at the dermoepidermal junction Adverse effects Skin blistering, dry skin, bone pain, headache, N&V, vertigo, ↑ transferases, hyperhistaminemia. See Retinal, Retinoic acid, Vitamin A.

tretinoin

A RETINOID drug used to treat ACNE, scaly skin conditions such as ICHTHYOSIS, skin ageing and certain forms of LEUKAEMIA. Brand names are Retin-A, Retinova and Vesanoid.

Tretinoin

A drug that works by increasing the turnover (death and replacement) of skin cells.
Mentioned in: Acne

tret·i·no·in

(tret'i-nō'in)
A keratolytic agent.

tretinoin (vitamin A acid, retinoic acid),

n brand name: Retin-A;
drug class: vitamin A acid;
action: decreases cohesiveness of follicular epithelium, decreases microcomedone formation;
use: treatment of acne vulgaris.

tretinoin

the all-trans stereoisomer of retinoic acid, used in dermatology for the treatment of disorders of keratinization. It is a potent teratogen and must be used with great caution.

Patient discussion about tretinoin

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More discussions about tretinoin
References in periodicals archive ?
All-trans retinoic acid antagonizes the action of calciferol and its active metabolite, 1,25-dihydroxycholecaliferol, in rats.
Data from an ongoing phase I/II study evaluating the safety and efficacy of the combination of Vidaza, valproic acid (VPA) and all-trans retinoic acid (ATRA) in patients with MDS and acute myelogenous leukemia (AML) were presented on Saturday, June 3.
Treatment with all-trans retinoic acid and anthracycline monochemotherapy for children with acute promyelocytic leukemia: a multicenter study by the PETHEMA Group.
A novel cytochrome P450, zebrafish Cyp26D1, is involved in metabolism of all-trans retinoic acid.
Since 1986, the innovative application of all-trans retinoic acid (ATRA) in APL treatment in China has dramatically improved the clinical outcome of patients, and the complete rate of remission has increased to 90-95 percent.
This favorable opinion for tamibarotene in the European Union (EU) is in addition to the Orphan Drug Designation for APL and Fast Track Designation for the treatment of adult patients with relapsed or refractory APL following treatment with all-trans retinoic acid (ATRA) and arsenic trioxide granted by the U.
In late 1998, the Company filed a New Drug Application for ATRAGEN (an injectable form of all-trans retinoic acid or tretinoin) for the treatment of patients with acute promyelocytic leukemia for whom therapy with tretinoin is necessary but for whom an intravenous administration is required.
Tamibarotene by itself inhibited the growth of these tumor cells two- to 10-fold more potently than all-trans retinoic acid (ATRA), a less specific relative of tamibarotene which has previously been shown to inhibit the growth of human myeloma cells.
In late 1998, the Company filed an NDA for ATRAGEN(R) (an injectable form of all-trans retinoic acid or tretinoin) for the treatment of patients with acute promyelocytic leukemia for whom therapy with tretinoin is necessary but for whom an intravenous administration is required.
The Fast Track Designation applies to the use of Tamibarotene in patients with relapsed or refractory APL following treatment with all-trans retinoic acid (ATRA) and arsenic trioxide.