tretinoin

(redirected from All-trans retinoic acid)
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Related to All-trans retinoic acid: Cis-retinoic acid

tretinoin

 [tret´ĭ-no″in]
the all-trans stereoisomer of retinoic acid, used topically for treatment of cases of acne vulgaris in which comedones, pustules, and papules predominate; it prevents comedo formation and suppresses keratin synthesis; common adverse effects are erythema and desquamation. It is also administered orally in treatment of acute promyelocytic leukemia.

tret·i·no·in

(tret'i-nō'in),
A keratolytic agent. See: retinoic acid.

tretinoin

/tret·i·noin/ (tret´ĭ-noin″) the all-trans stereoisomer of retinoic acid, used as a topical keratolytic in the treatment of acne vulgaris and disorders of keratinization and administered orally in the treatment of acute promyelocytic leukemia.

tretinoin

(trĕt′ĭ-noin′)
n.
An isomer of retinoic acid used topically to treat acne and to mitigate fine facial wrinkling and orally to treat one form of leukemia.

tretinoin

[tret′inō′in]
a retinoic acid derivative.
indications It is prescribed in the topical treatment of acne vulgaris and fine wrinkles and is administered orally for inducing remission in acute promyelocytic leukemia.
contraindications Known hypersensitivity to this drug or pregnancy prohibits its use.
adverse effects Among the more serious adverse effects of topical administration are photosensitivity and red, edematous, blistered, or crusted skin. Almost everybody taking the drug orally experiences some degree of weakness, fatigue, headache, and fever, but adverse effects are seldom reasons for discontinuing use of the drug.

tretinoin

A synthetic form of vitamin A used to treat acne, keratinisation (e.g., keratosis pilaris) and dermatitis. It also stimulates the immune system and is used to treat acute promyelocytic leukaemia. Retinoic acid is the naturally occurring form of the fat-soluble vitamin A, which is critical for the transportation of monosaccharides in glycoprotein synthesis, as occurs in the turnover of mucosal epithelia of the oral cavity and the respiratory and urinary tracts.

Toxicity
Skin blistering, crusting, headache, nausea, vomiting, vertigo.

tretinoin

all-trans-retinoic acid Dermatology A synthetic derivative of vitamin A used topically to reverse some of the effects of photoaging, both clinically–↓ skin wrinkling, improved skin texture and color and microscopically–↑ epidermal thickness, ↑ collagen and dermal vessels and 'erasing' epithelial atypia and dysplasia; tretinoin restores production of collagen I in photodamaged skin and lightens postinflammatory hyperpigmentation, it is also used for acne, keratinization, dermatitis, as a cancer preventive agent, and to induce terminal differentiation of acute promyelocytic leukemia, driving it into a mature nonproliferative state of remission Mechanism Unknown, possibly related to tretinoin's inhibition of collagenase, which degrades anchoring fibril collagen; tretinoin doubles the number of anchoring fibrils at the dermoepidermal junction Adverse effects Skin blistering, dry skin, bone pain, headache, N&V, vertigo, ↑ transferases, hyperhistaminemia. See Retinal, Retinoic acid, Vitamin A.

tretinoin

A RETINOID drug used to treat ACNE, scaly skin conditions such as ICHTHYOSIS, skin ageing and certain forms of LEUKAEMIA. Brand names are Retin-A, Retinova and Vesanoid.

Tretinoin

A drug that works by increasing the turnover (death and replacement) of skin cells.
Mentioned in: Acne

tret·i·no·in

(tret'i-nō'in)
A keratolytic agent.

tretinoin (vitamin A acid, retinoic acid),

n brand name: Retin-A;
drug class: vitamin A acid;
action: decreases cohesiveness of follicular epithelium, decreases microcomedone formation;
use: treatment of acne vulgaris.

tretinoin

the all-trans stereoisomer of retinoic acid, used in dermatology for the treatment of disorders of keratinization. It is a potent teratogen and must be used with great caution.

Patient discussion about tretinoin

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More discussions about tretinoin
References in periodicals archive ?
1997) Molecular remission in PML/RAR alpha-positive acute promyelocytic leukemia by combined all-trans retinoic acid and idarubicin (AIDA) therapy.
Extramedullary relapse after all-trans retinoic acid treatment in acute promyelocytic leukemia-the occurrence of retinoic acid syndrome is a risk factor.
All-trans retinoic acid in hematological malignancies.
9) The use of all-trans retinoic acid initiates differentiation of the immature myeloid cells and helps manage coagulopathy.
Modulation of ionizing radiation-induced apoptosis and cell cycle arrest by all-trans retinoic acid in promyelocytic leukemia cells (HL-60).
Huang M, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L, Go LJ, Wang ZY Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia.
Efficacy of antibiotic treatment for acne is very good, especially for inflammatory acne, and antibiotics are frequently used in combination with all-trans retinoic acid for non-inflammatory acne.
All-trans retinoic acid (RA) and 9-cis-retinoic acid (9cRA) are activators of Retinoic Acid Receptors (RARs).
It is well known that 9-cis and all-trans retinoic acid function as potent inducers of cell differentiation and inhibitors of cell proliferation.
All-trans retinoic acid (RA), a metabolite of vitamin A, acting through a plasma membrane retinoic acid-binding protein, has been shown to reduce electrical coupling between horizontal cells both in situ and between cell pairs in culture (10).