tretinoin

(redirected from All-Trans-Retinoic Acid)
Also found in: Dictionary, Acronyms.
Related to All-Trans-Retinoic Acid: Vesanoid

tretinoin

 [tret´ĭ-no″in]
the all-trans stereoisomer of retinoic acid, used topically for treatment of cases of acne vulgaris in which comedones, pustules, and papules predominate; it prevents comedo formation and suppresses keratin synthesis; common adverse effects are erythema and desquamation. It is also administered orally in treatment of acute promyelocytic leukemia.

tret·i·no·in

(tret'i-nō'in),
A keratolytic agent. See: retinoic acid.

tretinoin

/tret·i·noin/ (tret´ĭ-noin″) the all-trans stereoisomer of retinoic acid, used as a topical keratolytic in the treatment of acne vulgaris and disorders of keratinization and administered orally in the treatment of acute promyelocytic leukemia.

tretinoin

(trĕt′ĭ-noin′)
n.
An isomer of retinoic acid used topically to treat acne and to mitigate fine facial wrinkling and orally to treat one form of leukemia.

tretinoin

[tret′inō′in]
a retinoic acid derivative.
indications It is prescribed in the topical treatment of acne vulgaris and fine wrinkles and is administered orally for inducing remission in acute promyelocytic leukemia.
contraindications Known hypersensitivity to this drug or pregnancy prohibits its use.
adverse effects Among the more serious adverse effects of topical administration are photosensitivity and red, edematous, blistered, or crusted skin. Almost everybody taking the drug orally experiences some degree of weakness, fatigue, headache, and fever, but adverse effects are seldom reasons for discontinuing use of the drug.

tretinoin

A synthetic form of vitamin A used to treat acne, keratinisation (e.g., keratosis pilaris) and dermatitis. It also stimulates the immune system and is used to treat acute promyelocytic leukaemia. Retinoic acid is the naturally occurring form of the fat-soluble vitamin A, which is critical for the transportation of monosaccharides in glycoprotein synthesis, as occurs in the turnover of mucosal epithelia of the oral cavity and the respiratory and urinary tracts.

Toxicity
Skin blistering, crusting, headache, nausea, vomiting, vertigo.

tretinoin

all-trans-retinoic acid Dermatology A synthetic derivative of vitamin A used topically to reverse some of the effects of photoaging, both clinically–↓ skin wrinkling, improved skin texture and color and microscopically–↑ epidermal thickness, ↑ collagen and dermal vessels and 'erasing' epithelial atypia and dysplasia; tretinoin restores production of collagen I in photodamaged skin and lightens postinflammatory hyperpigmentation, it is also used for acne, keratinization, dermatitis, as a cancer preventive agent, and to induce terminal differentiation of acute promyelocytic leukemia, driving it into a mature nonproliferative state of remission Mechanism Unknown, possibly related to tretinoin's inhibition of collagenase, which degrades anchoring fibril collagen; tretinoin doubles the number of anchoring fibrils at the dermoepidermal junction Adverse effects Skin blistering, dry skin, bone pain, headache, N&V, vertigo, ↑ transferases, hyperhistaminemia. See Retinal, Retinoic acid, Vitamin A.

tretinoin

A RETINOID drug used to treat ACNE, scaly skin conditions such as ICHTHYOSIS, skin ageing and certain forms of LEUKAEMIA. Brand names are Retin-A, Retinova and Vesanoid.

Tretinoin

A drug that works by increasing the turnover (death and replacement) of skin cells.
Mentioned in: Acne

tret·i·no·in

(tret'i-nō'in)
A keratolytic agent.

tretinoin (vitamin A acid, retinoic acid),

n brand name: Retin-A;
drug class: vitamin A acid;
action: decreases cohesiveness of follicular epithelium, decreases microcomedone formation;
use: treatment of acne vulgaris.

tretinoin

the all-trans stereoisomer of retinoic acid, used in dermatology for the treatment of disorders of keratinization. It is a potent teratogen and must be used with great caution.

Patient discussion about tretinoin

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More discussions about tretinoin
References in periodicals archive ?
Binding of 9-cis-retinoic acid and all-trans-retinoic acid to retinoic acid receptors alpha, beta, and gamma.
All-Trans-Retinoic Acid Pharmacology and Its Impact on the Treatment of Acute Promyelocytic Leukemia.
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism.
TrentinoinLF is Argus' intravenous liposomal formulation of a retinoid compound called all-trans-retinoic acid (ATRA).
Later it became clear that the important mediator was the acid, all-trans-retinoic acid (tretinoin), and this was used instead.
Kligman [2] is credited with showing the effectiveness of topically applied all-trans-retinoic acid (ATRA) in improving the appearance of aged skin.
The review gives many classical references such as the studies of Wolbach & Howe (1925) on the effects of vitamin A and the skin, and deals with the issue from a cosmetic point of view, ignoring the use of retinoids in dermatological treatment (even the use of all-trans-retinoic acid [ATRA] for acne).
The present paper deals with the effect of a flavonoid from Citrus depressa called nobiletin applied topically to hamster auricle compared with all-trans-retinoic acid (ATRA), and also when added to cultures of hamster sebocytes.
However, all-trans-retinoic acid cream is only available on prescription and also tends to produce irritation in a majority of patients.
All-trans-retinoic acid (RA), a derivative of vitamin A, plays an important role in embryogenesis and early postnatal development.
Topical retinoids such as all-trans-retinoic acid, (ATRA, Accutane), Differin, and Tazorac, produce anti-inflammatory activities by downregulating TLR2 and CD14 mRNA, and this seems to be a specific action for TLR2, since there is very little measurable change in TLR4, for example.

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