ALK

(redirected from Alkes)

ALK

Abbreviation for:
activin-like kinase
anaplastic lymphoma kinase, see there

Genetics
A gene on 2p23 that encodes an orphan receptor with tyrosine kinase activity belonging to the insulin receptor superfamily, which plays an important role in brain development.

Molecular pathology
ALK is amplified, mutated and rearranged in various cancers, including anaplastic large cell lymphomas, neuroblastoma and non-small cell lung cancer. The most common genetic alterations seen in ALK malfunction are chromosomal rearrangements resulting in multiple fusion genes, including ALK/EML4, ALK/RANBP2 and ALK/ATIC (all on chromosome 2); ALK/TFG (on chromosome 3); ALK/NPM1 and ALK/SQSTM1 (both on chromosome 5); ALK/KIF5B (on chromosome 10); ALK/CLTC (on chromosome 17); ALK/TPM4 (on chromosome 19); and ALK/MSN (on X chromosome).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Commenting on these results, Alkes Price from the Harvard School of Public Health noted that because so many regions are implicated, there is the concern that "GWAS will ultimately implicate the entire genome, becoming uninformative." A clinically useful signal appears impossible to distinguish from the noise.
Madison, WI, USA) by using primers ALKES 1 and ALK-ER (2).
A Navy veteran of World War II, he served in the Pacific Theater as Lieutenant Commander and Supply Officer of the Attack Transport USS Alkes.
Jenny Cao-Nicole Alkes, 6-4, 2-6, 10-6; Liza Welch-Chloe Newell d.
Nhi Ho, 6-4, 2-6, 6-3; Jenny Cao-Nicole Alkes (S) d.
Stephanie Guerrero, 6-0, 6-1; Jenny Cao-Nicole Alkes (D) d.
Rose Payva, 6-4, ret.; Jenny Cao-Nichole Alkes (S) d.
Jenny Cao-Nicole Alkes, 6-4, 7-6, (7-5); Jackie Forson-Lisa Gitaw (S) d.
2 singles, while Iva Hoxha and Nicole Alkes won at second doubles for South.
Doubles winners were the teams of Ivy Jones-Sabrina Maliqi and Iva Hoxha-Nicole Alkes.