ALK

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ALK

Abbreviation for:
activin-like kinase
anaplastic lymphoma kinase, see there

Genetics
A gene on 2p23 that encodes an orphan receptor with tyrosine kinase activity belonging to the insulin receptor superfamily, which plays an important role in brain development.

Molecular pathology
ALK is amplified, mutated and rearranged in various cancers, including anaplastic large cell lymphomas, neuroblastoma and non-small cell lung cancer. The most common genetic alterations seen in ALK malfunction are chromosomal rearrangements resulting in multiple fusion genes, including ALK/EML4, ALK/RANBP2 and ALK/ATIC (all on chromosome 2); ALK/TFG (on chromosome 3); ALK/NPM1 and ALK/SQSTM1 (both on chromosome 5); ALK/KIF5B (on chromosome 10); ALK/CLTC (on chromosome 17); ALK/TPM4 (on chromosome 19); and ALK/MSN (on X chromosome).
References in periodicals archive ?
AB InBev said it would increase its prices from March 1, 2012 by 5.9 percent, while Alken Maes said it would up its prices by about 6 percent from March 12.
Arthropods from the Lower Devonian (Lower Emsian) of Alken an der Mosel, Germany, Pt.
The Magic of the Moselle Valley river cruise, meanwhile, takes in the picturesque villages of Alken, Cochem and Zell and also visits Trier and the famous Bernkastel market square.
But Alken, in various interviews where the subject has been broached, has chosen to neither confirm nor deny that he is gay.
A nineteenth-century drawing by the English artist Henry Thomas Alken, engraved by John Zeitten.
The Scottish & Newcastle group comprises Scottish Courage in the UK, Brasseries Kronenbourg in France, Alken Maes in Belgium, Centralcer in Portugal and the pub and restaurant operator S&N Retail.
On 15 July, the skipper of the Norwegian ship Alken was shown a strange bird by the crew.
Hane; Savannah River Site; Building 703-45A; Alken, SC 29808; Ph: (803) 725-5811; Fax: (803) 725-8727; E-mail: richard.hane@srs.gov
Available on a wide choice of dates from the end of May until the beginning of October, highlights include visits to the pretty riverside towns of Rudesheim, Alken, Zell and Cochem, along with the ancient cites of Koblenz and Cologne.