ALK

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ALK

Abbreviation for:
activin-like kinase
anaplastic lymphoma kinase, see there

Genetics
A gene on 2p23 that encodes an orphan receptor with tyrosine kinase activity belonging to the insulin receptor superfamily, which plays an important role in brain development.

Molecular pathology
ALK is amplified, mutated and rearranged in various cancers, including anaplastic large cell lymphomas, neuroblastoma and non-small cell lung cancer. The most common genetic alterations seen in ALK malfunction are chromosomal rearrangements resulting in multiple fusion genes, including ALK/EML4, ALK/RANBP2 and ALK/ATIC (all on chromosome 2); ALK/TFG (on chromosome 3); ALK/NPM1 and ALK/SQSTM1 (both on chromosome 5); ALK/KIF5B (on chromosome 10); ALK/CLTC (on chromosome 17); ALK/TPM4 (on chromosome 19); and ALK/MSN (on X chromosome).
References in periodicals archive ?
Since the agreement was signed, because of changes in SanDisk's markets and business, as well as capital market factors, the price has proven to be simply too high," Alken officials said, in a statement.
On 15 July, the skipper of the Norwegian ship Alken was shown a strange bird by the crew.
Hane; Savannah River Site; Building 703-45A; Alken, SC 29808; Ph: (803) 725-5811; Fax: (803) 725-8727; E-mail: richard.
The European Commission found Interbrew, domestic rival Alken Maes and several smaller players, guilty of operating illegal cartels in Belgium in the mid 1990s.
Available on a wide choice of dates from the end of May until the beginning of October, highlights include visits to the pretty riverside towns of Rudesheim, Alken, Zell and Cochem, along with the ancient cites of Koblenz and Cologne.
In March, French food group Danone announced that it would sell its beer business to Scottish & Newcastle, including Kronenbourg, Belgium's Alken Maes and its 24% stake in Peroni.
Six tour operators are offering travel packages for the event, and two of them, Alken Tours and Sunburst Holidays, are booking travel directly from Los Angeles.
For reviews of intracavernosal injection therapy, see Gingell, 1998; Jeunemann, Manning, Krautschick, & Alken, 1996).
The company will also retain and invest in the glass fiber wet mat manufacturing lines in Alken and the continuous filament mat lines in Huntingdon.
John Leech's pre-eminent contribution to the effect of the novels also awaits investigation, together with the work of other illustrators (notably Henry Alken or Hablot K.
Alken serial dilators were used to perform dilatation and 28-Fr Amplatz sheath was introduced into the collecting systems (Figure 1).
Tiselius HG Ackermann D Alken P Buck C Conort P Gallucci M et al.