nitazoxanide

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nitazoxanide

Alinia

Pharmacologic class: Antiprotozoal

Therapeutic class: Anti-infective

Pregnancy risk category B

Action

Impedes pyruvate:ferredoxin oxidoreductase enzyme-dependent electron transfer reaction, which is essential to anaerobic energy metabolism

Availability

Oral suspension: 100 mg/5 ml

Tablets: 500 mg

Indications and dosages

Diarrhea caused by Giardia lamblia or Cryptosporidium parvum

Adults and children ages 12 and older: 500 mg (tablet or 25 ml suspension) P.O. every 12 hours with food for 3 days

Children ages 4 to 11: 200 mg (10 ml suspension) P.O. every 12 hours with food for 3 days

Children ages 1 to 3: 100 mg (5 ml suspension) P.O. every 12 hours with food for 3 days

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:

• renal, hepatic, or biliary disease or dysfunction; immunodeficiency (including human immunodeficiency virus); diabetes mellitus (suspension)

• concurrent use of warfarin or other highly plasma protein-bound drugs

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 11 (tablets) or age 1 (suspension).

Administration

• Give with food.

• Because a single tablet contains more nitazoxanide than recommended for pediatric dosing, don't give tablets to children younger than age 11.

• Keep suspension container tightly closed and shake well before each use. Suspension may be stored for 7 days; after that, discard unused portion.

Adverse reactions

CNS: headache

GI: nausea, vomiting, diarrhea, abdominal pain

Interactions

Drug-drug. Warfarin and other highly plasma protein-bound drugs with narrow therapeutic index: competition for binding sites, resulting in increased nitazoxanide blood level and efficacy

Patient monitoring

• Monitor renal and liver function tests frequently in patients with renal, hepatic, or biliary dysfunction.

• Monitor blood glucose levels in diabetic patients taking oral suspension.

Patient teaching

• Instruct patient to take drug with food.

• Inform diabetic patient that oral suspension contains sucrose.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

nitazoxanide

A synthetic salicylamide derivative and antiprotozoal that is active against Cryptosporidium parvum or Giardia lamblia infection, and which appears to also have activity against hepatitis B and hepatitis C.

nitazoxanide

A thiazolide anti-infective drug used to treat diarrhoea caused by Cryptosporidium parvum , Giardia lamblia, Entamoeba histolytica , Blastocystis hominis , Clostridium difficile and rotavirus.
References in periodicals archive ?
Prior to the mepacrine, she did several rounds of anti-parasitics (Alinia, albendazole, mebendazole, ivermectin) with little change in histamine issues but improved health in other ways.
Within this framework, it has been found that positive HS (affiliative and self-enhancing) can effectively improve the mental health and interpersonal relationships of individuals, such as improving optimism and self-esteem (Martin et al., 2003), increasing positive emotions, enhancing LS (Alinia, Doosti, Dehshiri, & Heydari, 2009), and relieving depression and anxiety caused by stress (Martin et al., 2003).
(27.) Roohafza H, Heidari K, Alinia T, Omidi R, Sadeghi M, Andalib E, et al.
(1) In this study (N=40 patients with mild to moderate psoriasis), Alinia and colleagues' demonstrated just how lamentable compliance is for 1 year, even for the topical medication fluocinonide ointment.
In (Alinia et al., 2017), studies of the dynamics of lithospheric plates in eastern Ontario and western Quebec (Canada) during period 2008-2012 are presented.
[27.] Yadegarfar G, Alinia T, Gharaaghaji Asl R, Allahyari T, Sheikhbagloo R.
The governing equations for determining thermal buckling of imperfect sandwich plates were developed by Zakeri and Alinia [7].
Mohsen Alinia, 45, of Three Spires Avenue, Radford, admitted being concerned in the production of the class B drug cannabis.
Alexander, Anne Alexanyan, Karina Alhabash, Saleem Elias Ali, Christopher Alinia, Minoo Allagui, Ilhem Allan, Stuart Allmer, Thomas Alper, Meryl Alvares, Claudia Amaral, Adriana Amaya, Hector Ananny, Mike Anderson, C.W.
In trim.5 al anului Caragiale 2012, anul Nibirusilor, de taierea porcului, se vor alinia curbele: