nitazoxanide

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nitazoxanide

Alinia

Pharmacologic class: Antiprotozoal

Therapeutic class: Anti-infective

Pregnancy risk category B

Action

Impedes pyruvate:ferredoxin oxidoreductase enzyme-dependent electron transfer reaction, which is essential to anaerobic energy metabolism

Availability

Oral suspension: 100 mg/5 ml

Tablets: 500 mg

Indications and dosages

Diarrhea caused by Giardia lamblia or Cryptosporidium parvum

Adults and children ages 12 and older: 500 mg (tablet or 25 ml suspension) P.O. every 12 hours with food for 3 days

Children ages 4 to 11: 200 mg (10 ml suspension) P.O. every 12 hours with food for 3 days

Children ages 1 to 3: 100 mg (5 ml suspension) P.O. every 12 hours with food for 3 days

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:

• renal, hepatic, or biliary disease or dysfunction; immunodeficiency (including human immunodeficiency virus); diabetes mellitus (suspension)

• concurrent use of warfarin or other highly plasma protein-bound drugs

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 11 (tablets) or age 1 (suspension).

Administration

• Give with food.

• Because a single tablet contains more nitazoxanide than recommended for pediatric dosing, don't give tablets to children younger than age 11.

• Keep suspension container tightly closed and shake well before each use. Suspension may be stored for 7 days; after that, discard unused portion.

Adverse reactions

CNS: headache

GI: nausea, vomiting, diarrhea, abdominal pain

Interactions

Drug-drug. Warfarin and other highly plasma protein-bound drugs with narrow therapeutic index: competition for binding sites, resulting in increased nitazoxanide blood level and efficacy

Patient monitoring

• Monitor renal and liver function tests frequently in patients with renal, hepatic, or biliary dysfunction.

• Monitor blood glucose levels in diabetic patients taking oral suspension.

Patient teaching

• Instruct patient to take drug with food.

• Inform diabetic patient that oral suspension contains sucrose.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

nitazoxanide

an antiprotozoal agent used to treat diarrhea caused by Cryptosporidium parvum or Giardia lamblia.

nitazoxanide

A synthetic salicylamide derivative and antiprotozoal that is active against Cryptosporidium parvum or Giardia lamblia infection, and which appears to also have activity against hepatitis B and hepatitis C.

nitazoxanide

A thiazolide anti-infective drug used to treat diarrhoea caused by Cryptosporidium parvum , Giardia lamblia, Entamoeba histolytica , Blastocystis hominis , Clostridium difficile and rotavirus.
References in periodicals archive ?
We also test tinidazole, Alinia, Ivermectin, Biltricide, and others.
The governing equations for determining thermal buckling of imperfect sandwich plates were developed by Zakeri and Alinia [7].
Mohsen Alinia, 45, of Three Spires Avenue, Radford, admitted being concerned in the production of the class B drug cannabis.
Alexander, Anne Alexanyan, Karina Alhabash, Saleem Elias Ali, Christopher Alinia, Minoo Allagui, Ilhem Allan, Stuart Allmer, Thomas Alper, Meryl Alvares, Claudia Amaral, Adriana Amaya, Hector Ananny, Mike Anderson, C.
5 al anului Caragiale 2012, anul Nibirusilor, de taierea porcului, se vor alinia curbele:
VICTIM: Alinia Sarag, inset, died of TB last month.
The best are Alinia, Arun's, Avenues, Charlie Trotter's plus Everest and Seasons.
In addition, your doctor can prescribe Alinia or another anti-parasitic prescription drug for the first stage of your treatment.
Romark Laboratories, which manu factures nitazoxanide under the trade name Alinia, supported the study; the drug is approved for the treatment of Cryptosporidium- and Giardia-related diarrhea in adults and children.
Nyquist included rifaximin for simple traveler's diarrhea (but not in complex cases with bloody stool); tinidazole, a new agent for parasitic diseases; and Alinia (active ingredient nitazoxanide), which is approved for pediatric diarrhea caused by cryptosporidium or Giardia intestinalis.
Fortunately, the FDA recently approved a safe and effective medication called Alinia (nitazoxanide), a three-day treatment for children affected by Cryptosporidium and Giardia.