alfentanil


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alfentanil

 [al-fen´tah-nil]
an opioid analgesic of rapid onset and short duration derived from fentanyl; the hydrochloride salt is used as a primary agent for induction of general anesthesia, as an adjunct in maintenance of general anesthesia, and as an adjunct to regional or local anesthesia.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

alfentanil

A potent, short-acting opioid analgaesic and fentanyl analogue which is 10-fold stronger than morphine. It is an OP3 mu agonist.
 
Mechanism of action
Modulation of the sympathetic response to endotracheal intubation and surgical stimulation.
 
Cons
Profound respiratory depression and skeletal muscle rigidity.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

alfentanil

Anesthesiology An opioid analgesic that is 10-fold more potent than morphine Cons Profound respiratory depression and skeletal muscle rigidity. See Opioid anesthetic. Cf Muscle relaxant.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

alfentanil

A narcotic analgesic drug used before and during anaesthesia. A brand name is Rapifen.

alfentanil

A narcotic-type pain-killing drug. A brand name is Rapifen.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Cold allodynia and hyperalgesia in neuropathic pain: The effect of N-methyl-d-aspartate (NMDA) receptor antagonist ketamine - a double-blind, cross-over comparison with alfentanil and placebo.
Continuous infusions and small bolus doses of fentanyl, sufentanil and alfentanil have little effect on CBF and ICP.
We performed comparative studies on the isolation of SF and alfentanil (AF; used as an internal standard) from plasma using LLE and SPE methods, and extracts were assessed using GC-MS.
Haemodynamic parameters like HR and SBP were significantly alleviated at 1 min, 3 mins and 5 mins in post-intubation in rocuronium with magnesium sulphate group when compared with RR group and RC groups, which has similarities with the observations of meta-analysis done by Seong-Joo Park et al, who analysed the effects of magnesium sulphate pre-treatment with rocuronium intubation under propofol and alfentanil anaesthesia.
If short-acting drugs had been used (propofol, suxamethonium, alfentanil) the patient can be expected to resume spontaneous ventilation shortly.
After an overnight fast, general anesthesia was induced by a short-acting barbiturate and maintained by alfentanil hydrochloride.
However, in a previous study Driver et al [18] showed that optimal conditions for LMA insertion in non-premedicated patients were achieved when combination of alfentanil, midazolam and propofol was used.
Comparison between alfentanil, pethidine and placebo in the treatment of post-anaesthetic shivering.