Aldrich syndrome


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Wiskott-Aldrich syndrome

 [wis´kot awl´drich]
a congenital platelet storage pool disease, transmitted as an X-linked recessive trait, characterized by the triad of eczema, thrombocytopenia, and recurrent purulent infection. There is an inability to produce antibodies to polysaccharide antigens and increased susceptibility to infection with encapsulated bacteria such as Haemophilus influenzae,meningococcus, or pneumococcus. Called also Aldrich syndrome.

Wis·kott-Ald·rich syn·drome

(wis'kot awl'drich), [MIM*301000 and MIM*277970]
an immunodeficiency disorder occurring in male children and characterized by thrombocytopenia, eczema, melena, and susceptibility to recurrent bacterial infections; death occurs from severe hemorrhage or overwhelming infection; X-linked recessive inheritance, caused by mutation in the Wiskott-Aldrich syndrome protein (WASP) on chromosome Xp.
Synonym(s): Aldrich syndrome

Wis·kott-Ald·rich syn·drome

(wis'kot awl'drich), [MIM*301000 and MIM*277970]
an immunodeficiency disorder occurring in male children and characterized by thrombocytopenia, eczema, melena, and susceptibility to recurrent bacterial infections; death occurs from severe hemorrhage or overwhelming infection; X-linked recessive inheritance, caused by mutation in the Wiskott-Aldrich syndrome protein (WASP) on chromosome Xp.
Synonym(s): Aldrich syndrome

Aldrich syndrome

An X-R condition characterized by thrombocytopenia, eczema, bloody diarrhea–melena, ↑ risk of bacterial infection; death is due to hemorrhage or overwhelming sepsis, usually by age 10

Aldrich syndrome

A sex-linked RECESSIVE bleeding disorder of children featuring DERMATITIS, OTITIS MEDIA, a reduction in blood platelets (THROMBOCYTOPENIA) with intestinal bleeding and black stools and a deficiency of immune GLOBULINS. (Robert Anderson Aldrich, American paediatrician, b. 1917).

Aldrich,

Robert Anderson, U.S. pediatrician, 1917–.
Aldrich syndrome - Synonym(s): Wiskott-Aldrich syndrome
Wiskott-Aldrich syndrome - see under Wiskott
References in periodicals archive ?
The Wiskott Aldrich Syndrome. In: Ochs HD, Smith CIE, Puck JM, editors.
Isolation of a novel gene mutated in Wiskott Aldrich Syndrome. Cell 1994; 78: 635-44.
(8.) Orange JS, Stone KD, Turvey SE, The Wiskott Aldrich Syndrome. Cell Mol Life Sci 2004;61:2361-85.
The Wiskott Aldrich Syndrome. Clin Rev Allergy Immunol 2001; 20:61-86.
Mandy Hayhoe with11-month-old Jack, who suffers from Wiskott Aldrich Syndrome Picture: JASON ROBERTS/jr190109syndrome-2
Little Bradley Jacobs was born with Wiscott Aldrich syndrome which left him with no immune system.
The court heard she turned to booze over the death of her first child, Luke, from rare Wiskott Aldrich syndrome. Frances Cook, Director of the Howard League for Penal Reform, said the magistrates' decision to jail her was "an outrage, nobody is going to benefit from it."
Tania never left little Luke's side as he lay in hospital with agonising Wiskott Aldrich syndrome.