aldosterone antagonist

(redirected from Aldosterone inhibitor)

aldosterone

[al-dos´ter-ōn, al´do-ster-ōn″]

the main mineralocorticoid hormone secreted by the adrenal cortex, the principal biological activity of which is the regulation of electrolyte and water balance by promoting the retention of sodium (and, therefore, of water) and the excretion of potassium; the retention of water induces an increase in plasma volume and an increase in blood pressure. Its secretion is stimulated by angiotensin II.

aldosterone antagonist a compound that blocks the action of aldosterone; the group includes potassium sparing diuretics such as spironolactone that compete with aldosterone for receptor sites, thus blocking the aldosterone-dependent exchange of sodium and potassium in the distal tubule.

al·dos·ter·one an·tag·o·nist

an agent that opposes the action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention; these agents, for example, spironolactone, are useful in treating the hypertension of primary hyperaldosteronism or the sodium retention of secondary hyperaldosteronism.

al·dos·ter·one an·tag·o·nist

(al-dos'tĕr-ōn an-tag'ŏ-nist)

An agent that opposes the action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention; these agents (e.g., spironolactone) are useful in treating the hypertension of primary hyperaldosteronism, or the sodium retention of secondary hyperaldosteronism.

al·dos·ter·one an·tag·o·nist

(al-dos'tĕr-ōn an-tag'ŏ-nist)

Agent that opposes action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention.

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References in periodicals archive ?

* Aldosterone inhibitor doses much lower than in the reported case (3) cause significant suppression of digoxin results in the MEIA II assays

In cases where simultaneous treatment with aldosterone inhibitors is reported or known, ultrafiltration of the sample can only partly remove the inhibition and does not lead to a correct result.

Another clinically important finding of this study is the negative interference from compounds other than aldosterone inhibitors. Despite the fact that most immunoassays routinely used to measure digoxin have reasonably low cross-reactivities with the known physiologic hormones (<1%) (2), positive interference has been reported with therapeutically given steroids such as hydrocortisone (33), prednisolone, and other synthetic steroids (34).

* Interference from aldosterone inhibitors is a potential problem in an alarmingly high number of patients, in particular intensive care patients, and is not confined to single, difficult cases (38)

* Low cardiologic doses of aldosterone inhibitors produce limited inhibition only

Digoxin assays: frequent, substantial, and potentially dangerous interference by Spironolactone, canrenone, and other steroids

The diuretic and aldosterone inhibitor spironolactone (Aldactone), often prescribed to patients with chronic heart failure, may have the added benefit of preventing fractures, especially in men, according to a report in the July 8 issue of the Journal of the American College of Cardiology.

Heart failure medication may help prevent fractures

Chantemele, "Reviving the use of aldosterone inhibitors in treating hypertension in obesity," American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol.

The Association between Antihypertensive Medication Use and Blood Pressure Is Influenced by Obesity

Aldosterone inhibitors (spironolactone) may be suggested to improve pump function and survival in moderate-to-severe HF.

Ask the doctors

Aldosterone inhibitors have been shown to improve left ventricular remodeling in heart failure (2).

Changes in cardiac aldosterone and its synthase in rats with chronic heart failure: an intervention study of long-term treatment with recombinant human brain natriuretic peptide

While aldosterone inhibitors are used to treat refractory hypertension, they typically are not used in blacks, possibly because they haven't been well studied in that population, Harshfield said.