aldosterone antagonist
(redirected from Aldosterone inhibitor)aldosterone
[al-dos´ter-ōn, al´do-ster-ōn″]the main mineralocorticoid hormone secreted by the adrenal cortex, the principal biological activity of which is the regulation of electrolyte and water balance by promoting the retention of sodium (and, therefore, of water) and the excretion of potassium; the retention of water induces an increase in plasma volume and an increase in blood pressure. Its secretion is stimulated by angiotensin II.
aldosterone antagonist a compound that blocks the action of aldosterone; the group includes potassium sparing diuretics such as spironolactone that compete with aldosterone for receptor sites, thus blocking the aldosterone-dependent exchange of sodium and potassium in the distal tubule.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
al·dos·ter·one an·tag·o·nist
an agent that opposes the action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention; these agents, for example, spironolactone, are useful in treating the hypertension of primary hyperaldosteronism or the sodium retention of secondary hyperaldosteronism.
Farlex Partner Medical Dictionary © Farlex 2012
al·dos·ter·one an·tag·o·nist
(al-dos'tĕr-ōn an-tag'ŏ-nist)An agent that opposes the action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention; these agents (e.g., spironolactone) are useful in treating the hypertension of primary hyperaldosteronism, or the sodium retention of secondary hyperaldosteronism.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
al·dos·ter·one an·tag·o·nist
(al-dos'tĕr-ōn an-tag'ŏ-nist)Agent that opposes action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention.
Medical Dictionary for the Dental Professions © Farlex 2012