aldosterone antagonist

(redirected from Aldosterone antagonists)
Also found in: Dictionary, Encyclopedia.
Related to Aldosterone antagonists: Aldosterone inhibitor

aldosterone

 [al-dos´ter-ōn, al´do-ster-ōn″]
the main mineralocorticoid hormone secreted by the adrenal cortex, the principal biological activity of which is the regulation of electrolyte and water balance by promoting the retention of sodium (and, therefore, of water) and the excretion of potassium; the retention of water induces an increase in plasma volume and an increase in blood pressure. Its secretion is stimulated by angiotensin II.
aldosterone antagonist a compound that blocks the action of aldosterone; the group includes potassium sparing diuretics such as spironolactone that compete with aldosterone for receptor sites, thus blocking the aldosterone-dependent exchange of sodium and potassium in the distal tubule.

al·dos·ter·one an·tag·o·nist

an agent that opposes the action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention; these agents, for example, spironolactone, are useful in treating the hypertension of primary hyperaldosteronism or the sodium retention of secondary hyperaldosteronism.

al·dos·ter·one an·tag·o·nist

(al-dos'tĕr-ōn an-tag'ŏ-nist)
An agent that opposes the action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention; these agents (e.g., spironolactone) are useful in treating the hypertension of primary hyperaldosteronism, or the sodium retention of secondary hyperaldosteronism.

al·dos·ter·one an·tag·o·nist

(al-dos'tĕr-ōn an-tag'ŏ-nist)
Agent that opposes action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention.
References in periodicals archive ?
At discharge, ACEi and beta-blockers were prescribed adequately, but aldosterone antagonists were under prescribed.
* Aldosterone antagonists: a diuretic that helps rid the body of extra water and helps retain potassium; often prescribed for heart-failure patients
Aldosterone antagonists: Aldosterone antagonists may reduce free testosterone levels and compete with androgens binding at the sebaceous gland.
The important caveat regarding the aldosterone antagonists is that they should be used only in patients with an estimated glomerular filtration rate greater than 30 mL/min per 1.73 [m.sup.2] and a serum potassium level below 5.0 mEq/dL.
Table-3: Different aldosterone antagonists prescribed to patients.
The medications included beta blockers, aldosterone antagonists, and angiotensin-converting enzyme (ACE) inhibitors.
All of these therapies--angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, beta-adrenergic blocking agents (betablockers), aldosterone antagonists, hydralazine/ isosorbide dinitrate, implantable cardioverter defibrillators, and cardiac resynchronization therapy--are effective in treating heart failure, with the benefits outweighing the risks.
Aldosterone antagonists and digoxin are often added as cardiac function declines.
Of the vast agents available, there are five major pharmaceutical categories that focus on the management of chronic heart failure: diuretics, angiotensin converting enzyme inhibitors (ACE inhibitors), angiotensin II receptor blockers (ARBs), beta blockers, and aldosterone antagonists.