aldosterone antagonist

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Related to Aldosterone antagonists: Aldosterone inhibitor

aldosterone

 [al-dos´ter-ōn, al´do-ster-ōn″]
the main mineralocorticoid hormone secreted by the adrenal cortex, the principal biological activity of which is the regulation of electrolyte and water balance by promoting the retention of sodium (and, therefore, of water) and the excretion of potassium; the retention of water induces an increase in plasma volume and an increase in blood pressure. Its secretion is stimulated by angiotensin II.
aldosterone antagonist a compound that blocks the action of aldosterone; the group includes potassium sparing diuretics such as spironolactone that compete with aldosterone for receptor sites, thus blocking the aldosterone-dependent exchange of sodium and potassium in the distal tubule.

al·dos·ter·one an·tag·o·nist

an agent that opposes the action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention; these agents, for example, spironolactone, are useful in treating the hypertension of primary hyperaldosteronism or the sodium retention of secondary hyperaldosteronism.

al·dos·ter·one an·tag·o·nist

(al-dos'tĕr-ōn an-tag'ŏ-nist)
An agent that opposes the action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention; these agents (e.g., spironolactone) are useful in treating the hypertension of primary hyperaldosteronism, or the sodium retention of secondary hyperaldosteronism.

al·dos·ter·one an·tag·o·nist

(al-dos'tĕr-ōn an-tag'ŏ-nist)
Agent that opposes action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention.
References in periodicals archive ?
Registry OPTIMIZE- ESC-HF ADHERE-I (4) HF (2) PILOT (3) Number of patients 48,612 1,892 10,171 Region USA Europe International- Asia Pacific * Age, years 73 70 67 Male 48 62 57 Diabetes mellitus 41 35 45 Atrial fibrillation 31 43 24 Median EF 39 38 -- HFpEF 51 35 47 ADCHF/DenovoAHF NA 75/25 64/36 IHD etiology 46 50 NA ACS precipitating factor 14 NA NA Beta blocker 83 81 41 ACEi/ARB 83 78 63 Aldosterone antagonists NA 54 31 In-hospital mortality 3.
The important caveat regarding the aldosterone antagonists is that they should be used only in patients with an estimated glomerular filtration rate greater than 30 mL/min per 1.
Total patients receiving aldosterone antagonists in some form###33(47.
In the UCLA study, which was published in the April 2, 2013 issue of the Journal of the American College of Cardiology, researchers found that the greatest gain in quality-adjusted life years for patients was achieved when ACE inhibitors, beta blockers, and aldosterone antagonists were used in conjunction with a diuretic.
The researchers calculate optimal use of the guideline-recommended heart failure therapies would save an additional 67,996 lives each year, including 21,407 from optimal use of aldosterone antagonists.
Currently, two aldosterone antagonists are available commercially.
The aim of this prospective observational study was to evaluate the association between ACEIs, ARBs and aldosterone antagonist spironolactone use and risk of postoperative AF development in patients with mild and moderate left ventricular systolic dysfunction.
Joe is taking an angiotensin-converting enzyme (ACE) inhibitor, a beta-blocker, an aldosterone antagonist, a loop diuretic, a nitrate, and digoxin, and he has an implantable cardioverter defibrillator (ICD).
We found that some of the available medications may not be as effective in women, while other therapies, for example, beta blockers, aldosterone antagonists and pacemakers, may be very beneficial," said Dr.
Aldosterone antagonists improve mortality but require close monitoring for severe hyperkalemia.
A-HeFT compared BiDil with placebo in black men and women with moderate to severe HF who were on standard HF therapies, including ACE inhibitors, angiotensin receptor blockers, aldosterone antagonists, as well as digitalis and diuretics.