aldosterone

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aldosterone

 [al-dos´ter-ōn, al´do-ster-ōn″]
the main mineralocorticoid hormone secreted by the adrenal cortex, the principal biological activity of which is the regulation of electrolyte and water balance by promoting the retention of sodium (and, therefore, of water) and the excretion of potassium; the retention of water induces an increase in plasma volume and an increase in blood pressure. Its secretion is stimulated by angiotensin II.
aldosterone antagonist a compound that blocks the action of aldosterone; the group includes potassium sparing diuretics such as spironolactone that compete with aldosterone for receptor sites, thus blocking the aldosterone-dependent exchange of sodium and potassium in the distal tubule.

al·dos·ter·one

(al-dos'tĕr-ōn), Avoid the mispronunciation aldoster'one.
A mineralocorticoid hormone produced by the zona glomerulosa of the adrenal cortex; its major action is to facilitate potassium exchange for sodium in the distal renal tubule, causing sodium reabsorption and potassium and hydrogen loss; the principal mineralocorticoid. It exists in equilibrium with the aldehyde form.

aldosterone

(ăl-dŏs′tə-rōn′)
n.
A steroid hormone that is produced by the adrenal cortex and regulates salt balance, blood volume, and blood pressure in the body.

aldosterone

An adrenocortical mineralocorticoid that controls electrolyte and water homeostasis by regulating reabsorption of Na+ and Cl– in exchange for K+ and H+, and which maintains blood pressure and blood volume. Aldosterone secretion is controlled by the RAA system and by concentrations of K+ in the circulation, which if increased evokes secretion of aldosterone. Reduced Na+ evokes renin release, which stimulates aldosterone secretion; aldosterone may be measured when evaluating hypertension.

Increased in
Adrenocortical adenoma or carcinoma, bilateral adrenal hyperplasia, renovascular hypertension, liver disease, congestive heart failure, cirrhosis, nephrotic syndrome, pregnancy (3rd trimester).

Decreased in
Primary hypoaldosteronism, salt-losing syndrome, eclampsia/toxemia of pregnancy, Addison’s disease (chronic adrenal insufficiency).
 
Ref range
• Serum, ≤ 20 mg/dL.
• Urine, ≤ 20mg/24 hours.

aldosterone

Endocrinology An adrenocortical mineralocorticoid hormone that controls the body's electrolyte and water homeostasis by regulating reabsorption of Na+ and Cl– in exchange for K+ and H+ ions, and maintaining BP and blood volume; aldosterone secretion is controlled by the RAA system and by concentrations of K+ in the circulation, which if ↑, evokes secretion of aldosterone; ↓ Na+ evokes renin release, which stimulates aldosterone secretion; aldosterone may be measured when evaluating HTN; aldosterone is ↑ in adrenocortical adenoma or CA, bilateral adrenal hyperplasia, renovascular HTN, liver disease, CHF, cirrhosis, nephrotic syndrome, pregnancy–3rd trimester; it is ↓ in 1º hypoaldosteronism, salt-losing syndrome, toxemia of pregnancy, Addison's disease Ref range Serum, ≤ 20 mg/dL; ≤ 20mg/24hrs, urine. See Hypertension, Pseudoaldosterone, Timed collections.

al·dos·ter·one

(al-dos'tĕr-ōn)
A hormone produced by the cortex of the suprarenal gland; its major action is to facilitate potassium exchange for sodium in the distal renal tubule, causing sodium reabsorption and potassium and hydrogen loss; the principal mineralocorticoid.

aldosterone

One of the STEROID hormones produced by the outer part of the adrenal gland. Aldosterone is concerned with the control of salt and water loss in the urine.

aldosterone

a hormone of the cortex of the ADRENAL GLAND. It is responsible for the relative concentration of sodium and potassium ions in the body. It promotes the reabsorption of sodium ions from the ascending limb of the LOOP OF HENLE in the kidney, with the elimination of potassium ions, and increases the uptake of sodium ions by the alimentary canal. The concentration of sodium ions in the blood thus rises and potassium ions fall, making possible the ionic regulation of body fluids (see SODIUM PUMP).

Aldosterone

A hormone secreted by the adrenal glands that is important for maintaining salt and water balance in the body.

al·dos·ter·one

(al-dos'tĕr-ōn) Avoid the mispronunciation aldoster'one.
Mineralocorticoid hormone produced by the zona glomerulosa of the cortex of the suprarenal gland that facilitates potassium exchange for sodium in the distal renal tubule, causing sodium reabsorption and potassium and hydrogen loss.
References in periodicals archive ?
Fonksiyonel adenom vakalarinin 9'u Cushing sendromu, 3'u feokromositoma, 3'u aldosteron ureten adrenal adenom idi.
Hipertansif olgulardan 3'unun tanisi aldosteron ureten adrenal adenom idi.
Bu 7 olgunun 2'si Cushing sendromu, 1'i feokromasitoma, 1'i aldosteron ureten adenom, 3'u non-fonksiyone lezyondu.
Ozellikle uygunsuz hiperaldosteronizm olan durumlar icin aldosteron antagonisti olan spironolakton onerilmekte ve diger diuretiklerle birlikte kullanilmasi tavsiye edilmektedir (19).
Hastaligin karakteristik bulgulari hiponatremi, hiperkalemi, metabolik asidoz, yuksek aldosteron ve renin duzeyidir (1).
Erken semptom gorulmesi, yuksek aldosteron duzeyi ve gunluk 30 mmol/kg'i asan tuz alimi kuvvetle sistemik psodohipoaldosteronizm tip 1'i dusundurur (1).
Plazma aldosteron duzeyi cok degisken olup; genellikle normaldir ve mineralo-kortikoidlere yeterli cevap vardir (2).
Aldosteron, kardiyak fibroblastlari ve matriks metalloproteinazlari uyararak daha fazla fibrozis oluiturabilir (16).
Ozet olarak, AT-2 ve aldosteron, atriyal remodeling geligiminde onemli hormonlardir.
Bildirilen vakanin aksine olgumuzda tiroid fonksiyon testleri ve aldosteron duzeyi normal sinir araliginda tespit edildi.
Amac: Bu (calismada tiazidlerin aldosteron antagonistleri ile kombine edilmelerinin, fibrinolitik aktivite uzerine tiazidlerin yaptigi olumsuz etkileri azaltabileceginin arastirilmasi hedeflenmistir.
Spironolakton gibi aldosteron antagonisti bir ajanla kombine kullanimi hipofibrinolitik ve metabolik yan etkilerini azalttigi sonucuna varilmistir.