fructose-bisphosphate aldolase

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fruc·tose-bis·phos·phate al·dol·ase

(fruk'tōs bis-fos'fāt al'dol-ās),
Fructose-1,6-bisphosphate triophosphate-lyase; an enzyme reversibly cleaving fructose 1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate; also acts on certain ketose 1-phosphates; deficient in individuals with hereditary fructose intolerance (aldolase B isozyme); a deficiency of aldolase A leads to erythrocyte aldolase deficiency with nonspherocytic hemolytic anemia. Compare: hereditary fructose intolerance.
Synonym(s): 1, 6-diphosphofructose aldolase, 1-phosphofructaldolase, diphosphofructose aldolase, fructoaldolase, fructose 1, 6-bisphosphate triosephosphate-lyase, fructose 1, 6-diphosphate aldolase, fructose 1-monophosphate aldolase, fructose 1-phosphate aldolase, fructose-diphosphate aldolase, ketose-1-phosphate aldolase, phosphofructoaldolase, SMALDO, zymohexase
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Our data confirm, on a quantitative basis, the strong resurgence of aldolase A in HCC at the mRNA level.
The various mRNA aldolase A species found in human tissues differ in the 5' noncoding region because of alternative splicing (24), and one of these is expressed by human fetal liver cells.
Therefore, quantitative analysis of their mRNA species can be added to the analysis of aldolase A mRNA as a contributory tool for the diagnosis of HCC.
In conclusion, the noncompetitive RT-PCR procedure for aldolase A mRNA quantitative analysis described here is highly efficient, reproducible, and with small cost, can be extended to the analysis of other mRNA species.