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(i-mi-kwi-mod) ,


(trade name),


(trade name),


(trade name)


Therapeutic: antivirals
Pharmacologic: immune response modifiers
Pregnancy Category: C


External genital or perianal warts/condylomata (condyloma acuminatum).Typical, nonhyperkeratotic, nonhypertrophic actinic keratoses on the face or scalp.Biopsy-confirmed, primary superficial basal cell carcinoma (Aldara only).


May induce the formation of interferons that have antiproliferative and antiviral properties.

Therapeutic effects

Regression of external genital or perianal warts/condylomata, actinic keratoses, or basal cell carcinoma lesions.


Absorption: Minimal absorption.
Distribution: Action is primarily local.
Metabolism and Excretion: <0.9% excreted in urine and feces.
Half-life: Unknown.

Time/action profile (regression of lesions)

Topicaldays–wk10–16 wkunknown


Contraindicated in: None known.
Use Cautiously in: Previous treatment/surgery in affected area (area should be healed prior to use);Pre-existing inflammatory skin lesions (may be exacerbated);Immunocompromised patients (safety not established); Obstetric / Lactation / Pediatric: Pregnancy, lactation, or children <12 yr (safety not established).

Adverse Reactions/Side Effects

Central nervous system

  • dizziness
  • fatigue
  • headache


  • diarrhea
  • nausea


  • dysuria
  • vulvar swelling


  • irritation (most frequent)
  • pain (most frequent)
  • pruritus (most frequent)
  • burning (most frequent)
  • swelling (most frequent)
  • fungal infections (women)


Drug-Drug interaction

None known.


External Genital Warts

Topical (Adults and children ≥12 yr) Aldara—Apply thin layer to warts at bedtime every other day (3 times weekly); leave on for 6–10 hr, then rinse off with mild soap and water. Use until lesions are completely cleared or up to 16 wk. Zyclara—Apply thin layer of 3.75% cream to warts at bedtime every day; leave on for 8 hr, then rinse off with mild soap and water. Use until lesions are completely cleared or up to 8 wk.

Actinic Keratoses

Topical (Adults) Aldara—Apply thin layer to clean, dry affected area twice weekly; leave on for 8 hr, then rinse off with mild soap and water. Continue for 16 wk. Zyclara—Apply thin layer of 2.5% or 3.75% cream to clean, dry affected area once daily before bedtime; leave on for 8 hr, then rinse off with mild soap and water. Continue for 2 wk, followed by 2 wk without treatment, then begin applying cream again for another 2 wk.

Superficial Basal Cell Carcinoma

Topical (Adults) Apply thin layer to clean, dry affected area 5 times per week; leave on for 8 hr, then rinse off with mild soap and water. Continue for 6 wk.

Availability (generic available)

Cream: 2.5% in single-use packets and pump bottles (Zyclara), 3.75% in single-use packets and pump bottles (Zyclara), 5% in single-use packets (Aldara)

Nursing implications

Nursing assessment

  • Assess affected area(s) prior to and periodically during therapy.

Potential Nursing Diagnoses

Risk for infection (Indications)
Risk for infection (Patient/Family Teaching)


  • Do not confuse Aldara (imiquimod) with Alora (estradiol).
  • Topical: Apply a thin film to clean and dry skin as directed prior to bedtime. Rub in well and leave on skin for time period specified. Remove by washing with mild soap and water. Discard unused cream from single-dose packet. A rest period of several days may be taken if required for patient comfort or severity of skin reaction. Resume therapy when reaction subsides.
    • Do not use occlusive dressings. If covering is needed, use cotton gauze or cotton underclothes.

Patient/Family Teaching

  • Instruct patient on proper application technique. Emphasize the importance of washing hands before and after application and avoiding contact with eyes. Advise patient not to use more cream than was prescribed. Missed doses should be applied as soon as possible; then return to regular schedule.
  • Advise patient to delay next dose for several days when experiencing discomfort or severe reactions. Notify health care professional if severe reactions occur.
  • Advise patient to avoid sharing this medication with others.
  • Instruct patient to avoid contact with affected areas while the cream is on the skin. Wash cream off of genital areas before engaging in sexual activities. Inform patient that oils in the cream weaken latex contraceptive devices, such as cervical caps, condoms, and diaphragms.
  • Advise patient to avoid use of other topical medications on same treatment area unless recommended by health care professional.

Evaluation/Desired Outcomes

  • Healing of genital or perianal warts. Treatment is continued until wart is healed or up to 16 wk.
  • Healing of actinic keratosis. Treatment is continued for 16 wk.
  • Resolution of superficial basal cell carcinoma lesions. Treatment is continued for 6 wk.
Drug Guide, © 2015 Farlex and Partners


A proprietary topical immune response modifier, which is used to manage actinic keratosis, superficial basal cell carcinomas, and external genital warts.
Adverse effects Rash at application site, upper respiratory tract infection, squamous carcinoma of skin.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Salvage can also be done by crossing over to Aldara or just by close observation, giving treatment when an invasive malignancy occurs.
Cecconi et al., "Aldara activates TLR7-independent immune defence," Nature Communications, vol.
Son sus autores Vanessa Werneck Bartoli Pires (Coordinadora de Buenas Practicas de Fabricacion en la Empresa Vilma Alimentos de Brasil); Angelita Pereira Batista (Profesora Adjunta de la Universidade Federal Fluminense-UFF, Brasil); Raquel Pereira de Souza (Profesora Adjunta de la Universidade Federal Fluminense-UFF, Brasil); y Aldara da Silva Cesar (Profesora Adjunta de la Universidade Federal FluminenseUFF, Campus de Volta Redonda-RJ y Lider del Grupo de Analise de Sistemas Agroindustriais del CNPQ, en Brasil).
"It can also cause irritant dermatitis, which is a difficult problem when you already have a kid who may be atopic and you're trying to treat molluscum." Also, according to the package insert for Aldara cream, imiquimod administered three times per week for 16 weeks was not shown to be superior to vehicle alone in two randomized, controlled trials that were completed in 2006 but never published.
That component includes such medicines as the dermatologic treatment Aldara, the hypertension medication Tiazac and the diabetes drug Glumetza.
Every fortnight, I give a powerpoint presentation to groups of people who are undergoing topical treatment (Efudix, Aldara or Picato) for superficial skin cancers and sun-damaged skin, explaining how the treatments work, educating them about how to manage their skin throughout the treatment, and supporting them through the process.
Section 1.4 of the "indications and usage" section of the package insert now reads: "Aldara cream has been evaluated in children ages 2-12 years with molluscum contagiosum and these studies failed to demonstrate efficacy." Dr.
The use of a chemotherapeutic agent such as 5-Fluorouracil or Aldara (Imiquimod), can prevent development of skin cancer.
The firm will be working with the Aldara Medical Corporation to deliver Phase II of the Aldara Hospital and Medical Centre in Riyadh.
"Arabtec is winning larger, more complex projects such as The Louvre Abu Dhabi; airport projects such as the Midfield Terminal Building at Abu Dhabi International Airport; and hospital projects such as Aldara Hospital in Saudi Arabia," the company said in a statement.