Alcohol Flush Reaction


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A condition caused by the incomplete metabolism of alcohol with accumulation of acetaldehyde due to a missense polymorphism in acetaldehyde dehydrogenase—ALDH2—resulting in bright red skin due to capillary dilation of face, neck, shoulder, and sometimes the entire body after consuming alcohol. Those with ALDH2 deficiency have up to a 10-fold greater risk of oesophageal cancer, attributed to the accumulation of acetaldehyde
References in periodicals archive ?
Washington, Jan 20 (ANI): Chinese researchers hold rice responsible for the alcohol flush reaction, an unpleasant response to alcohol that is relatively common in people of Asian descent.
People carrying an ALDH2*2 allele show an alcohol flush reaction, even when they consume only relatively small amounts of alcohol (Peng et al.
KEY WORDS: Alcohol use disorder; alcohol and other drug (AOD)-related (AODR) mortality; AOD use, abuse, and dependence; alcoholism; East Indians; Native American; Southwest California Indians; genetic factors; genetic polymorphisms; protective factors; alcohol flush reaction; ethanol metabolism; alcohol dehydrogenase (ADH); aldehyde dehydrogenase (ALDH); acetaldehyde; ALDH1; ALDH2; ALDH2*2; ALDH1A1*2; ADH1B; ADH1B*3
KEY WORDS: Ethanol metabolism; ethanol-to-acetaldehyde metabolism; acetaldehyde; aldehyde dehydrogenases (ALDHs); alcohol dehydrogenase (ADH); alcohol metabolite; catalase; brain; central nervous system; protective factors; alcohol flush reaction; pharmacology and toxicology