A “first-generation” ultrasound contrast medium consisting of a solution of air-filled microbubbles (mean bubble size 4 µm, range 1–10 µM) produced by sonicating 5% albumin solution, which enhances ultrasonographic imaging of the heart, fallopian tubes, and other structures.
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The first FDA approved contrast agent used in the US was Albunex (since discontinued) in 1994, which was only approved for echocardiology [36].
For example, after passage through the heart, Albunex lasts for only 15-30 seconds, and Optison for about 2 minutes.
* Albunex consisted of air filled human albumin microspheres of size 1-8 [micro] for use in myocardial contrast echocardiography (4).

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