loratadine

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Related to Alavert: loratadine

loratadine

 [lah-rat´ah-dēn]
a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria and as a treatment adjunct in asthma; administered orally.

loratadine

Aerius (CA), Alavert, Allertin, Claritin, Claritin RediTabs, Clarityn (UK)

Pharmacologic class: Histamine1-receptor antagonist (second-generation)

Therapeutic class: Antihistamine (nonsedating)

Pregnancy risk category B

Action

Selective histamine1-receptor antagonist. Blocks peripheral effects of histamine release during allergic reactions, decreasing or preventing allergy symptoms.

Availability

Syrup: 1 mg/ml

Tablets: 10 mg

Tablets (rapidly disintegrating): 10 mg

Indications and dosages

Seasonal allergies; chronic idiopathic urticaria

Adults and children ages 6 and older: 10 mg P.O. daily

Children ages 2 to 5: 5 mg P.O. daily

Dosage adjustment

• Renal or hepatic impairment

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:
• renal or hepatic impairment
• elderly patients
• pregnant patients
• children younger than age 2 (safety not established).

Administration

• Give once a day on empty stomach.
• Place rapidly disintegrating tablet on tongue; give with or without water.
• Use rapidly disintegrating tablets within 6 months of opening foil pouch and immediately after opening individual tablet blister.

Adverse reactions

CNS: headache, nervousness, insomnia

EENT: conjunctivitis, earache, epistaxis, pharyngitis

GI: abdominal pain; dry mouth; diarrhea, stomatitis (in children)

Skin: rash, photosensitivity, angioedema

Other: tooth disorder (in children), fever, flulike symptoms, viral infections

Interactions

Drug-food.Any food: increased drug absorption

Patient monitoring

• Watch for adverse reactions, especially in children.
• Assess patient's response to drug.
• Watch for new symptoms or exacerbation of existing symptoms.

Patient teaching

• Advise patient to take exactly as prescribed, once a day on empty stomach.
• Tell patient to report persistent or worsening symptoms.
• Instruct patient to report adverse reactions, such as headache or nervousness.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the foods mentioned above.

loratadine

/lor·at·a·dine/ (lah-rat´ah-dēn) a nonsedating antihistamine used in the treatment of allergic rhinitis, chronic idiopathic urticaria, and asthma.

loratadine

(lôr-ăt′ə-dēn′)
n.
A nonsedating antihistamine, C22H23ClN2O2, used to treat allergic rhinitis and other allergic disorders.

loratadine

[lärat′ädēn]
a nonsedating antihistamine (H1-receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria and as a treatment adjunct in asthma, administered orally.

loratadine

An ANTIHISTAMINE drug used to treat hay fever and other allergic disorders.

antihistamine 

Any substance that reduces the effect of histamine or blocks histamine receptors, usually the histamine 1 (H1) receptor. It is used in the treatment of allergic conjunctivitis and also in the temporary relief of minor allergic symptoms of the eye. Common agents include antazoline sulfate, azelastine hydrochloride, cetirizine, chlorphenamine, emedastine, epinastine hydrochloride, ketotifen, levocabastine, loratadine and olopatadine. See hypersensitivity; mast cell stabilizers.

loratadine

(lərat´ədēn),
n brand name: Claritin;
drug class: antihistamine, H1 histamine antagonist;
action: acts on blood vessels, gastrointestinal system, respiratory system by competing with histamine for H1-receptor site; decreases allergic response by blocking histamine;
uses: seasonal rhinitis, allergy symptoms, idiopathic chronic urticaria.
References in periodicals archive ?
any conflict of interest regarding Alavert or Whitehall-Robbins.
As retailers nationwide were preparing for the launch of the OTC nonsedating antihistamines (NSAs) Claritin and Alavert in 2002, there were many questions regarding the incremental revenue these new products would bring, what impact they would have on the leading brands, and how much space should be allocated to them.
Medicate: You can get various antihistamines over the counter; Claritin and its generic equivalent, Alavert, are effective for many allergy sufferers.
s Claritin, for example, had more equity at the time it went O-T-C than Wyeth's Alavert or private label loratadine products because of its prescription heritage, explains Doyle.
Wyeth's loratadine tablet product, Alavert, sold nearly $59 million in its first year, 2003, and gained slightly in 2004 with sales of $59.
Revenues from Wyeth declined from a year ago, as we were shipping launch quantities of Alavert during the first quarter of 2003.
For the quarter, Organon's Remeron SolTabs, Wyeth's Alavert, and AstraZeneca's Zomig continued to be our major revenue generators.
From Claritin and Alavert to Prilosec OTC to new forms of smoking-cessation products, the past two years have seen a number of prominent switches that bring a wider array of options to consumers.
We hit the high end of our third-quarter guidance range for revenue on strong sales of Remeron SolTabs and Alavert to our partners.
Wyeth Consumer Healthcare's Alavert, another product switched from prescription to over-the-counter status, dropped three places to seventh.