alanine transaminase

(redirected from Alanine transferase)

alanine transaminase

 [al´ah-nēn trans-am´ĭ-nās]
an enzyme that catalyzes the reversible transfer of an amino group from alanine to α-ketoglutarate to form pyruvate and glutamate. Normally present in many tissues and body fluids, especially in the liver, it is released into the serum as a result of tissue injury; the serum concentration is increased particularly when there is acute damage to hepatic cells, as in viral or toxic hepatitis, infectious mononucleosis, and obstructive jaundice. Called also alanine aminotransferase and glutamic-pyruvic transaminase.

al·a·nine a·mi·no·trans·fer·ase (ALT),

(al'ă-nēn a-mē'nō-tranz'fer-ās),
An enzyme transferring amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); one d-alanine transaminase effects the same reaction, but using d-alanine and d-glutamate. Serum concentration is increased in viral hepatitis and myocardial infarction.

al·a·nine a·mi·no·trans·fer·ase

(ALT) (al'ă-nēn ă-mē'nō-trans'fĕr-ās)
An enzyme transferring amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction.
Synonym(s): glutamic-pyruvic transaminase, serum glutamic-pyruvic transaminase.

al·a·nine a·mi·no·trans·fer·ase

(ALT) (al'ă-nēn ă-mē'nō-trans'fĕr-ās)
An enzyme transferring amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction.
Synonym(s): glutamic-pyruvic transaminase, serum glutamic-pyruvic transaminase,
alanine transaminase.
References in periodicals archive ?
During the examination, he was found to have leukocytosis, thrombocytopenia, jaundice, hepatitis B-positive, and deranged liver enzymes [aspartate transferase (AST) and alanine transferase (ALT) >1000 IU/L].
Laboratory tests indicated hypoxaemia in arterial blood gas analysis (pH 7.43, partial pressure of carbon dioxide (pC[O.sub.2]) 45.5 mmHg, partial pressure of oxygen (p[O.sub.2]) 54.7 mmHg) and mildly elevated liver enzymes (aspartate aminotransferase (AST) 68 IU/L, alanine transferase (ALT) 72 IU/L).
Aspartate transferase and alanine transferase were determined by the methods of Reitman and Frankel (1957).
(2012) A significant reduction (P<0.05) was observed in the specific activities of alanine transferase (ALT) in various organs of the broilers chick fed with raw and processed L.
Alanine transferase, aspartate trasnferrase, alkaline phosphatase and gamma-glutamyl transpeptidase levels were 946, 1047, 396 and 203 U/L, respectively.
An 80-year old lady was referred to a gastroenterology clinic in August 2009 with deranged liver function tests; alkaline phosphatase 180 IU/L (35-120), alanine transferase 147 IU/L (<40), gamma glutamyl transferase 384 IU/L (<45) and globulins 45 g/L (20-35).
Patients in the teriflunomide group experienced more nausea, diarrhea, increases in alanine transferase, and hair thinning than did those in the placebo group, but these effects were mild.
Three days after admission, acute renal failure with relative oliguria (0.85 L/24 h) developed, as well as uremia (26.4 mg/dL), creatinemia (0.98 mg/ dL), and abnormal liver function (aspartate aminotransferase 49 U/L and alanine transferase 60 U/L).
At the end of therapy, normalization of alanine transferase occurred in 14/33 treated patients (42.4%) and HCV-RNA was cleared in 12 (36.4%).
The most common grade 3-4 biochemical abnormalities were alanine transferase elevation (13%), bilirubin (25%), hypophosphatemia (32%), lipase elevation (44%), and hyperglycemia (33%), Dr.
As a result, in mice administered the anti-CXCL10 neutralizing antibody the serum alanine transferase (ALT3) level was significantly lower, and histologically too the area of necrotized hepatic cells was strikingly reduced.
Serum alanine transferase levels declined in patients receiving rosglitazone, perhaps because the drug decreased liver fat content.