AIDS dementia complex

(redirected from Aids dementia)

AIDS de·men·ti·a com·plex (ADC),

a subacute or chronic HIV-1 encephalitis, the most common neurologic complication in the later stages of HIV infection; manifested clinically as a progressive dementia, accompanied by motor abnormalities.

AIDS Dementia Complex

An insidious metabolic encephalopathy affecting up to two-thirds of AIDS patients, which is triggered by HIV and driven by neurotoxins secreted by macrophages and microglia. It may be complicated by infections—e.g., Toxoplasma gondii, CMV, or lymphomas.
Clinical findings Poor concentration, loss of memory, incoordination, dysgraphia, lethargy, apathy.
Note: 30% of asymptomatic HIV-positive subjects have EEG abnormalities or progressive cognitive, motor, or behavioural dysfunction.

AIDS dementia complex

AIDS An insidious–30% of asymptomatic HIV-positive subjects have EEG abnormalities, progressive cognitive, motor, behavioral dysfunction, which affects up to 2⁄3 of AIDS Pts; ADC may be complicated by infections–eg, Toxoplasma gondii, CMV, lymphomas Clinical Inability to concentrate, loss of memory, gait incoordination, dysgraphia, slowing of psychomotor functions and eventually, apathy Pathology Degeneration of subcortical white matter and deep gray matter, white matter vacuolization in the lateral and posterior columns of the spinal cord

AIDS dementia complex

A feature of certain cases of AIDS in which there is so much direct damage to brain cells by HIV that DEMENTIA occurs. The condition occurs in some 20% of people with untreated AIDS in the late stages. The drug ZIDOVUDINE appears to be capable of greatly reducing the likelihood of this effect. Other anti-AIDS drugs may be less useful in preventing ADC.

AIDS dementia complex

A type of brain dysfunction caused by HIV infection that causes difficulty thinking, confusion, and loss of muscular coordination.
Mentioned in: AIDS

AIDS de·men·ti·a com·plex

(ADC) (ādz dĕ-menshē-ă kompleks)
Subacute or chronic HIV-1 encephalitis, the most common neurologic complication in the later stages of HIV infection.
References in periodicals archive ?
Evidence for a change in aids dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of aids dementia complex.
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Neuropsychological characterization of the AIDS dementia complex: a preliminary report.
The researchers analysed samples of blood and cerebrospinal fluid from HIV-infected subjects who were taking efavirenz in the North Eastern AIDS Dementia study.
For the study led by Haughey, researchers obtained samples of blood and cerebrospinal fluid from HIV-infected subjects enrolled in the NorthEastern AIDS Dementia study who were taking efavirenz.
RNA viroid induced mRNA interference can contribute to cell death in AIDS dementia, malignant transformation and autoimmunity in the acquired immunodeficiency syndrome.
Timed gait test: normative data for the assessment of the AIDS dementia complex.
A doctor confirmed that they were now more aware of the tools to help identify and diagnose AIDS dementia, and the potential interventions for treatment.
1) HIV-associated dementia (HAD) has also been referred to as HIV encephalopathy or AIDS dementia complex.
Most entries have been revised, including those on autism spectrum disorders, atherosclerosis, learning disabilities, neurofibromatosis, polio, rabies, antidepressants, aphasia, AIDS dementia complex, Alzheimer's disease, ADHD, and chronic fatigue and immune dysfunction syndrome.
The HIV-positive subjects were classified into three groups: 124 were neurologically asymptomatic, 66 had AIDS dementia complex (ADC) stage 0.
HIV encephalopathy is part of the acute HIV syndrome during seroconversion whereas AIDS dementia complex, also known as HIV-associated dementia complex, is characterised by cognitive, motor and behavioural features in advanced AIDS when the CD4 lymphocyte count falls below 200 cells/[mm.

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