GNAS

(redirected from Aho)
Also found in: Acronyms, Wikipedia.

GNAS

A locus on chromosome 20q13.3 that has a highly complex imprinted expression pattern, giving rise to maternally, paternally and biallelically expressed transcripts derived from four alternative promoters and 5' exons. Some transcripts have a differentially methylated region (DMR) at their 5' exons. This DMR is commonly found in imprinted genes and correlates with transcript expression; one transcript produced from this locus and the antisense transcript are paternally expressed, noncoding RNAs, which may regulate regional imprinting. Alternative splicing of downstream exons results in different forms of the stimulatory G-protein alpha subunit, a key component of the classical signal-transduction pathway linking receptor-ligand interactions to adenylyl cyclase activation and various cellular responses.

Molecular pathology
GNAS mutations have been linked to pseudohypoparathyroidism types 1a and 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone and pituitary tumours.
References in periodicals archive ?
Peter Aho mixed aggression with caution, and he was whittle down the target and Nigeria were helped over the line by the cheering Ugandan crowd.
That catchy tune blared again three times in the second, twice courtesy of Aho. He tied it with a short-handed goal 89 seconds into the second, then scored the go-ahead goal with a kneeling-down shot from the slot at 7:11.
[2] Nonstandard abbreviations: PHP, pseudohypoparathyroidism; AHO, Albright hereditary osteodystrophy; PPHP, pseudo-PHP.
Aho has practiced what she preaches for the business and at home.
The reflection on human suffering is carried over to the final section on "Health and Illness." Here Aho draws on Tolstoy, Nietzsche, and those existential thinkers who distinguish the material body from the lived body to argue that "healing has less to do with the objective metrics of the biological body than with how we choose to interpret and give meaning to our embodiment." For existentialists, suffering and death are part of what makes us human and thus must be meaningfully integrated into our lives rather than falsely sought to be eradicated.
According to Aho, this "gives the work a ritualistic character--as if the solo horn brings something from afar to the audience and orchestra and, when all is said and done, disappears from view." Without the visuals accompanying a live performance of the piece, it is still striking to hear the horn spatially represented from within the recording as coming from different locations.
Hummel had a disabled daughter at the time he wrote his will, which included donating funds for the Pearl Buck Center, Aho said.
As a result, Aho said he believes per capita pork consumption will stay flat and beef consumption will fall over the coming decade.
"A lot of Japanese veterinarians would come to Hawaii on vacation and would buy a lot of U.S products to take back," says Teresa Lynch, AHO president.
Written by Hristov, Kaarle Aho. Reviewed at Sofia Film Festival (competing), March 10, 2011.
In his new role, Aho will be responsible for functions covering central banking and Group treasury, business control, business intelligence, investor relations, capital management and strategies and projects.
It is added that NOKIA Executive Board Member Esko Aho sent a letter to the Ministry, apologizing for the "unfortunate situation and the entirely non-intentional inconvenience and tension caused to the Government and the people" of the Republic of Cyprus.