Ah receptor

Ah receptor

A receptor that is detectable in many tissues and organs which binds various environmental pollutants, including polycyclic aromatic hydrocarbons, hetercyclic amines and polychlorinated aromatic compounds (e.g., dioxins, dibenzofurans and biphenyls), and mediates the well-known carcinogenic effects of these agents. Once bound via a helix-loop-helix motif and activated, the Ah receptor-ligand complex is transported to the nucleus where it binds to specific DNA sequences and variously turns genes on or off.
References in periodicals archive ?
Characterization of 2,3,7,8-tetrachlorodibenzofurandependent suppression and AH receptor pathway gene expression in the developing mouse mammary gland.
Protein-DNA interactions at a dioxin-responsive enhancer: mutational analysis of the DNA-binding site for the liganded Ah receptor," The Journal of Biological Chemistry, vol.
Activation of the Ah receptor by extracts of dietary herbal supplements, vegetables, and fruits.
However, green tea now seems to be the best drink-based defence as it also contains chemicals which `shut down' the action of a molecule known as the AH receptor, which plays a key role in the development of tumours.
The aromatic hydrocarbon (Ah) gene battery (1) comprises Ah receptor (AHR), its nuclear translocator (ARNT), and the genes that encode the detoxifying enzymes of phase I (e.
These so-called knockout mice proved sickly, suggesting that the body needs the Ah receptor for healthy development (SN: 5/6/95, p.
com/research/30dc32/the_ah_receptor_in) has announced the addition of John Wiley and Sons Ltd's new book "The AH Receptor in Biology and Toxicology" to their offering.
Daily cycle of bHLH-PAS proteins, Ah receptor and Arnt, in multiple tissues of female Sprague-Dawley rats.
Now, toxicologists at the University of California, Davis report that carbaryl, one of the most widely used insecticides, turns on the Ah receptor in liver cells despite having a shape remarkably unlike dioxins.
The initial step in dioxin toxicity requires the binding to, and transformation of the Ah receptor to a DNA-binding form that then affects the expression of several gene products.
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor.