Ah receptor

Ah receptor

A receptor that is detectable in many tissues and organs which binds various environmental pollutants, including polycyclic aromatic hydrocarbons, hetercyclic amines and polychlorinated aromatic compounds (e.g., dioxins, dibenzofurans and biphenyls), and mediates the well-known carcinogenic effects of these agents. Once bound via a helix-loop-helix motif and activated, the Ah receptor-ligand complex is transported to the nucleus where it binds to specific DNA sequences and variously turns genes on or off.
References in periodicals archive ?
Tullis et al., "Activation of the Ah receptor by tryptophan and tryptophan metabolites," Biochemistry, vol.
Perdew, "Role of the ah receptor in homeostatic control of fatty acid synthesis in the liver," Toxicological Sciences, vol.
Ligand binding and activation of the Ah receptor. Chem Biol Interact 141(1-2):3-24.
Whitlock Jr., "Protein-DNA interactions at a dioxin-responsive enhancer: mutational analysis of the DNA-binding site for the liganded Ah receptor," The Journal of Biological Chemistry, vol.
Bradfield, "Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development," Proceedings of the National Academy of Sciences of the United States of America, vol.
Activation of the Ah receptor by extracts of dietary herbal supplements, vegetables, and fruits.
However, green tea now seems to be the best drink-based defence as it also contains chemicals which `shut down' the action of a molecule known as the AH receptor, which plays a key role in the development of tumours.
Responsiveness of the adult male rat reproductive tract to 2,3,7,8-tetrachlorodibenzo-pdioxin exposure: Ah receptor and ARNT expression, CYPIA1 induction, and Ah receptor down-regulation.
These so-called knockout mice proved sickly, suggesting that the body needs the Ah receptor for healthy development (SN: 5/6/95, p.
Bjeldanes, "Lipoxin A4: a new class of ligand for the Ah receptor," Biochemistry, vol.
Daily cycle of bHLH-PAS proteins, Ah receptor and Arnt, in multiple tissues of female Sprague-Dawley rats.