Aggressive Digital Papillary Adenocarcinoma

Aggressive Digital Papillary Adenocarcinoma

A rare, often painful variant of sweat gland carcinoma that occurs on the palmo-plantar surfaces of the hand and foot and which may become clinically aggressive. It is more common in men, has a mean age at presentation of 52, averages 1.7 cm in greatest dimension and may be present for up to 15 years. The term "aggressive digital papillary adenoma" has been abandoned, given that despite their bland appearance, they often behave aggressively.
Prognosis Up to 14% metastasise; 40–50% recur locally.
Management Aggressive surgical re-resection or amputation if necessary to avoid local recurrence.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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The entity "aggressive digital papillary adenoma" was initially described in 1979 by Helwig at the Armed Force Institute of Pathology (AFIP) who later differentiated between "aggressive digital papillary adenoma" and "aggressive digital papillary adenocarcinoma" in a 1987 case series [1,3].
The histopathological differential diagnosis included a primary sweat gland carcinoma (aggressive digital papillary adenocarcinoma) as well as a metastatic adenocarcinoma from an upper gastrointestinal or pancreaticobiliary tract origin.
[11] likened ADPA to melanoma in its predilection for metastasis and adapted the concept of sentinel lymph node biopsy (SLN) in the treatment of aggressive digital papillary adenocarcinoma in 2000.
Asgari, "Is aggressive digital papillary adenocarcinoma really aggressive digital papillary adenocarcinoma?" Dermatology Practical & Conceptual, vol.
Chuang, "Aggressive digital papillary adenocarcinoma: a review," Clinical and Experimental Dermatology, vol.
Takehara, "Lymphatic mapping and sentinel lymph node biopsy for staging of aggressive digital papillary adenocarcinoma," Plastic and Reconstructive Surgery, vol.
Katsuoka, "Aggressive digital papillary adenocarcinoma on the palm with pulmonary metastases," Journal of Dermatology, vol.
(7) These include adenoid cystic eccrine carcinomas, aggressive digital papillary adenocarcinomas, eccrine adenocarcinomas, and mucinous eccrine carcinomas.

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