Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes.
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.
Inoki et al., "Brevican is degraded by matrix metalloproteinases and aggrecanase-1
(ADAMTS4) at different sites," The Journal of Biological Chemistry, vol.
In this study, we examined the effects of different concentrations of IL-1[beta] and TGF-[beta]1 on the production of collagen II, aggrecanase-1, aggrecanase-2, and aggrecan in chondrocytes, in order to explain the mechanism of IL-1[beta] and TGF-[beta]1 on chondrocyte differentiation.
IL-1[beta] at the concentration of 10 ng/ml resulted in a maximal induction of aggrecanase-1 and aggrecanase-2 in chondrocytes.
Aggrecanase-1 and/or aggrecanase-2 is the enzymes responsible for aggrecan cleavage during cytokine-induced cartilage degradation [14-16].
Okada, "Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1
) and ADAMTS5 (aggrecanase-2)," Biochemical and Biophysical Research Communications, vol.
Yonezawa et al., "MicroRNA-125b regulates the expression of aggrecanase-1
(ADAMTS-4) in human osteoarthritic chondrocytes," Arthritis Research & Therapy, vol.
Fujita et al., "Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1
(ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-[kappa]B," The American Journal of Pathology, vol.
Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1
) in the trans-Golgi network.
Lentivirus-mediated knockdown of aggrecanase-1 and -2 promotes chondrocyte-engineered cartilage formation in vitro.
Effects of RNAi-mediated inhibition of aggrecanase-1 and aggrecanase2 on rat costochondral chondrocytes in vitro.