ADAMTSae4

(redirected from Aggrecanase-1)

ADAMTSae4

An ADAMTSs family enzyme encoded by ADAMTS4 on chromosome 1q21-q23, which cleaves aggrecan, the major proteoglycan of cartilage, the proteolytically active form of which may require removal of the prodomain by furin-like activity and part of the C-terminal spacer domain by other matrix metalloproteinases. ADAMTS4 is found mainly in brain, lung, heart, chondrocytes and in joint tissues from arthritic rats (and presumably arthritic patients). ADAMTS4 and ADAMs family members are upregulated in breast cancer.
References in periodicals archive ?
Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes.
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.
Inoki et al., "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites," The Journal of Biological Chemistry, vol.
In this study, we examined the effects of different concentrations of IL-1[beta] and TGF-[beta]1 on the production of collagen II, aggrecanase-1, aggrecanase-2, and aggrecan in chondrocytes, in order to explain the mechanism of IL-1[beta] and TGF-[beta]1 on chondrocyte differentiation.
IL-1[beta] at the concentration of 10 ng/ml resulted in a maximal induction of aggrecanase-1 and aggrecanase-2 in chondrocytes.
Aggrecanase-1 and/or aggrecanase-2 is the enzymes responsible for aggrecan cleavage during cytokine-induced cartilage degradation [14-16].
Okada, "Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2)," Biochemical and Biophysical Research Communications, vol.
Yonezawa et al., "MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes," Arthritis Research & Therapy, vol.
Fujita et al., "Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-[kappa]B," The American Journal of Pathology, vol.
Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network.
Lentivirus-mediated knockdown of aggrecanase-1 and -2 promotes chondrocyte-engineered cartilage formation in vitro.
Effects of RNAi-mediated inhibition of aggrecanase-1 and aggrecanase2 on rat costochondral chondrocytes in vitro.