aggrecanase


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aggrecanase

(ag-gre'ka-nāz),
An enzyme found in cartilage that degrades extracellular matrix, especially cartilage.
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References in periodicals archive ?
Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.
The aggrecanase and proteoglycanase clades (ADAMTS1, 4, 5, 8, 9, 15, and 20) can cleave hyaluronan-binding chondroitin sulfate proteoglycans, a type of extracellular proteins, including aggrecan, versican, brevican, and neurocan [2].
Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.
East et al., "ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro," Nature, vol.
Decicco et al., "Aggrecanase: a target for the design of inhibitors of cartilage degradation," Annals of the New York Academy of Sciences, vol.
Trzaskos, "Aggrecanase: a target for the design of inhibitors of cartilage degradation," Annals of the New York Academy of Sciences, vol.
ADAMTS1, -4, -5, -8, -9 and -15 have aggrecanase activity whereas other members do not.