aggrecan


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ag·gre·can

(ag're-kan),
Candidate gene for otosclerosis located at 15q25 to q26.

Aggrecan

A proteoglycan expressed in variant forms through alternative splicing which, with type II collagen, is a major component of articular cartilage and other cartilaginous tissues. Aggrecan is broken down by the ADAMTSs (A Disintegrin And Metalloprotease with ThromboSpondin) protein family, ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2). ADAMTS1 processes aggrecan and forms a covalent-binding complex with alpha2-macroglobulin which is dependent on the zinc-binding site.

ag·gre·can

(ag'rĕ-kan)
Candidate gene for otosclerosis located at 15q25-q26.

aggrecan

An extracellular PROTEOGLYCAN that forms exceptionally large aggregates giving cartilage its particular gel-like properties and resistance to deformation.
References in periodicals archive ?
Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.
COMP is an abundant cartilage extracellular matrix protein that interacts with major cartilage components including aggrecan and collagens.
Dauber, "Idiopathic short stature due to novel heterozygous mutation of the aggrecan gene," Journal of Pediatric Endocrinology and Metabolism, vol.
(a, c) The expression of type II collagen, aggrecan, Cytokeratin 8, MAP-1, MAP-2, and MAP-4 proteins noticeably decreased compared with that before loading.
Tenascin-R and CSPGs such as aggrecan generally represent principal PNN components in the mature brain [1].
Studies of cartilage explants report decreases in the density of glycosaminoglycan within the proteoglycan molecule, decreases in aggrecan molecule size and density, and increases in cartilage matrix degradation products such as low molecular weight hyaluronic acid and biglycan (25).
(22,23) Genetic transcription of chondrocytes increase the production of aggrecan when influenced by mechanotransduction.
ADAMTS-1 is a MMP that has been implicated in the inhibition of angiogenesis induced by luteinizing hormone (LH) in the periovulatory follicles of the mouse and rat and is also thought to be a mediator of proteolytic cleavage of the hyaluronan binding proteoglycans, aggrecan, and versican (16,17).
Salter, "Mechanotransduction via integrins and interleukin-4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes," Arthritis & Rheumatism, vol.
On the other hand, studies that evaluated immune responses towards different citrullinated proteins, such as citrullinated vimentin and citrullinated aggrecan in RA patients, demonstrated a certain degree of immune cell stimulation directed to these citrullinated proteins [25, 26].