agglutinin

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Related to Agglutinins: Cold agglutinins

agglutinin

 [ah-gloo´tĭ-nin]
any substance causing agglutination (clumping together) of cells, particularly a specific antibody formed in the blood in response to the presence of an invading agent. Agglutinins are proteins (immunoglobulins) and function as part of the immune mechanism of the body. When the invading agents that bring about the production of agglutinins are bacteria, the agglutinins produced bring about agglutination of the bacterial cells.

Erythrocytes also may agglutinate when agglutinins are formed in response to the entrance of noncompatible blood cells into the bloodstream. A transfusion reaction is an example of the result of agglutination of blood cells brought about by agglutinins produced in the recipient's blood in response to incompatible or foreign cells (the donor's blood). Anti-Rh agglutinins are produced in cases of Rh incompatibility and can result in a condition known as erythroblastosis fetalis when the maternal blood is Rh negative and the fetal blood is Rh positive. (See also rh factor.)
cold agglutinin antibody that agglutinates erythrocytes or bacteria more efficiently at temperatures below 37°C than at 37°C.
group agglutinin one that has a specific action on certain organisms, but will agglutinate other species as well.
H agglutinin one that is specific for flagellar antigens of the motile strain of an organism.
immune agglutinin a specific agglutinin found in the blood after recovery from the disease or injection of the microorganism.
incomplete agglutinin one that at appropriate concentrations fails to agglutinate the homologous antigen.
O agglutinin one specific for somatic antigens of a microorganism.
platelet agglutinin an antibody capable of agglutinating platelets; these may be associated with a variety of disorders, with and without frank thrombocytopenia.
warm agglutinin an incomplete antibody that sensitizes and reacts optimally with erythrocytes at 37°C.

ag·glu·ti·nin

(ă-glū'ti-nin),
1. An antibody that causes clumping or agglutination of the bacteria or other cells that either stimulated the formation of the agglutinin, or contain immunologically similar, reactive antigen. Synonym(s): agglutinating antibody, immune agglutinin
2. A substance, other than a specific agglutinating antibody, that causes organic particles to agglutinate, for example, plant agglutinin.

agglutinin

(ə-glo͞ot′n-ĭn)
n.
A substance, such as an antibody, that is capable of causing agglutination of a particular antigen, especially red blood cells or bacteria.

Agglutinin

Medspeak Any antigenic substance capable of agglutinating. See Neuroprotective agglutinin, 2-adrenoceptor agglutinin, Cold agglutinin, Febrile agglutinin, Mixed fieldagglutinin.

ag·glu·ti·nin

(ă-glū'ti-nin)
1. An antibody that causes clumping or agglutination of the bacteria or other cells that either stimulated the formation of the agglutinin or contain immunologically similar, reactive antigen.
2. A substance, other than a specific agglutinating antibody, that causes organic particles to agglutinate.

agglutinin

A substance that causes cells or other particles to clump together and, usually, to lose their former properties. ‘Warm’ agglutinins function at normal body temperatures; ‘cold’ agglutinins do so at lower temperatures. Agglutinins can cause severe ANAEMIA.

Agglutinin

An antibody that causes particulate antigens such as bacteria or other cells to clump together.

ag·glu·ti·nin

(ă-glū'ti-nin)
Antibody that causes clumping or agglutination of the bacteria or other cells that either stimulated the formation of the agglutinin or contain immunologically similar, reactive antigen.
References in periodicals archive ?
[139] showed that the covalent surface modification of microparticles containing a gemcitabine derivative with wheat germ agglutinin (WGA) resulted in enhancing of binding duration on urothelial cells; bound microparticles were able to withstand the extensive washout and improved antiproliferative activity [139].
Particles of an antigen will only clump together in the presence of the specific agglutinin to that antigen.
Primary Chronic Cold Agglutinin Disease: An update on Pathogenesis, clinical features and Therapy.
The variability of hemolysis in the cold agglutinin syndrome.
A lipopolysaccharide binding agglutinin isolated from brown shrimp (Penaeus californiensis Holmes) haemolymph.
Epidemiological survey on anti-leptospire agglutinins in buffaloes from Vale do Ribeira (Brazil).
The serum was therefore, subjected to standard tube agglutination test (SAT--suspension of pure smooth culture of Brucella abortus strain 99 in phenol saline, IVRI, Izatnagar) to know the titre of brucella agglutinins. The patient showed alarmingly high titres of 10,240 IU/ml with SAT.
The effectiveness of this system is also dictated by inherently produced oligosaccharides, which are attached to MUC7 mucin and other proteins called agglutinins. If these oligosaccharides are capable of binding with the cariogenic bacteria, they form proteinbacteria aggregates while still in the fluid phase of the saliva.
A serological survey for Brucella canis agglutinins in dogs using the macroscopic tube agglutination test.
Formation of cold agglutinins is frequently observed during Mycoplasma pneumoniae infections.
Test results for malaria (blood smear), agglutinins for typhoid fever, and surface antigen of hepatitis B virus were negative.
For example, patients with Mycoplasma pneumoniae infections, the presence of cold agglutinins is useful in diagnosis.