COLUMN A COLUMN B Agenerase
Retrovir plus Hivid Fortovase Videx plus Epivir Norvir Rescriptor Viracept plus Fortovase Viramune Ziagen
Approval of Agenerase
provides a significant new medicine for the treatment of HIV," says Lynn Smiley, vice president of HIV and opportunistic infections clinical development at Glaxo Wellcome.
The most commonly reported adverse events associated with Agenerase
in clinical trials have been nausea, vomiting, headache, and rash.
However, with a new version of Invirase being developed and the recent re-creation of Agenerase
as Lexiva, the pill burden may be significantly decreased, making this treatment combination easier to take in the future.
Lexiva is a new version of the drug Agenerase
and is taken in combination with other HIV drugs.
On February 5, 2002, FDA approved a new dosing regimen for Agenerase
(amprenavir) and Norvir (ritonavir) used in combination.
Note 6: In the first quarter of 2008, the Company recognized royalty revenues based on actual and estimated net sales of Lexiva/Telzir and Agenerase
by GlaxoSmithKline plc under the Company's 1993 license agreement with GlaxoSmithKline plc.
TABLE: Currently approved medications for treating HIV/AIDS Protease Entry Nukes Non-nukes Inhibitors Inhibitors Combivir Rescriptor Agenerase
Fuzeon (Epivir + Retrovir) Emtriva Sustiva Crixivan Epivir Viramune Fortovase Hivid Invirase Retrovir Kaletra Trizivir (Epivir + Lexiva Retrovir + Ziagen) Videx (regular or EC) Norvir Viread Reyataz Zerit Viracept Ziagen
amprenavir Combivir [AZT+3TC] Crixivan indinavir Epivir lamivudine (3TC) Fortovase saquinavir Hivid zalcitabine (ddC) Kaletra lopinavir/ritonavir Norvir ritonavir Rescriptor delavirdine Retrovir zidovudine (AZT) Sustiva efavirienz Trizivir [abacavir+AZT+3TC] Videx didanosine (ddI) Viracept nelfinavir Viramune nevirapine Viread tenofovir DF Zerit stavudine (d4T) Ziagen abacavir
GW433908 (also known as 908 or fosamprenavir) is an experimental PI that will basically be a new formulation of the PI Agenerase
, which is considered difficult to take because of the size of the pills and the number required for each dose, The new formulation decreases the pill count and size.
The reason this drug is important is that the current version of Agenerase
requires taking 16 large capsules a day.
First, taking Agenerase
and Methadone is not recommended because Agenerase
lowers the levels of Methadone in the blood, and Agenerase
may not be absorbed as well when taken with Methadone.