afterdepolarization

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afterdepolarization

[af″ter-de-po″lah-rĭ-za´shun]

an oscillation in membrane potential that is dependent upon a preceding action potential for its initiation, and which upon reaching threshold potential can induce arrhythmias that are said to be “triggered.” Early afterdepolarizations occur during phases 2 and 3 of repolarization; delayed afterdepolarizations follow full repolarization.

afterdepolarization

/af·ter·de·po·lar·iza·tion/ (af″ter-de-po″lar-ĭ-za´shun) a depolarizing afterpotential, frequently one of a series, sometimes occurring in tissues not normally excitable. It may occur before (early a.) or after (delayed a.) full repolarization.

afterdepolarization

[-dēpō′lərizā′shən]

a membrane potential depolarization that follows an action potential. In cardiac muscles, it may be early (during phases 2 and 3 of the action potential) or delayed (during phase 4), and it is thought to cause atrial and ventricular tachycardia, especially in the setting of a long Q-T interval or digitalis poisoning. Also called afterpotential.

afterdepolarization

in myocardial activity a polarization, sufficient to trigger a cardiac cycle, which results from a preceding impulse or series of impulses.

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References in periodicals archive ?

a physician researcher and colleagues studied early afterdepolarizations (EADs), an abnormal depolarization during the plateau phase of the heart electrical activity (action potential) that can initiate arrhythmia, and a hallmark of LQTS.

What drives sudden cardiac death

Canine left ventricular hypertrophy predisposes to ventricular tachycardia induction by phase 2 early afterdepolarizations after administration of BAY K 8644.

Prospective cohort study of lead exposure and electrocardiographic conduction disturbances in the department of veterans affairs normative aging study

Distinct patterns of calcium transients during early and delayed afterdepolarizations induced by isoproterenol in ventricular myocytes.

Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines.

The aqueous extract, not organic extracts, of Terminalia arjuna bark exerts cardiotonic effect on adult ventricular myocytes

Afterdepolarizations as a mechanism for the long QT syndrome: electrophysiologic studies of a case.

Causes and management of drug-induced long QT syndrome

Dietary fish oil reduces the occurrence of early afterdepolarizations in pig ventricular myocytes.

Averting arrhythmias with omega-3 fatty acids

On the one hand, prolonged repolarization durations found at the LV apex and adjacent areas under LV overload may provoke early afterdepolarizations.

Effect of the left ventricular overload on epicardial repolarization in the rabbit

Therapeutic concentrations of ranolazine (2 uM to 6 uM) suppressed early afterdepolarizations and reduced dispersion, two important predictors of a drug's anti-arrhythmic potential.

Circulation Publishes Study of Ranolazine Demonstrating Important Cardiac Ion Channel Effects

currents, leading to the development of early afterdepolarizations (EADs) and slow response APs (4) observed in mXin[alpha]-/- myocytes.

Changes in ionic currents and reduced conduction velocity in hypertrophied ventricular myocardium of Xin[alpha]-deficient mice

Functional consequences of elimination of i(to,f) and i(to,s): early afterdepolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.

Metal particulate matter components affect gene expression and beat frequency of neonatal rat ventricular myocytes

ATX-II elicits early afterdepolarizations (EADs) and ventricular tachycardia (VT) in these models by selective activation of the late sodium channel in the heart.

Three Studies Evaluating Electrophysiological Properties Of Ranolazine Presented at NASPE Scientific Sessions

Early afterdepolarizations (EADs) are abnormal delays in the repolarization of the heart, and can initiate ventricular tachycardias (VT) in this model.