afterdepolarization

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afterdepolarization

 [af″ter-de-po″lah-rĭ-za´shun]
an oscillation in membrane potential that is dependent upon a preceding action potential for its initiation, and which upon reaching threshold potential can induce arrhythmias that are said to be “triggered.” Early afterdepolarizations occur during phases 2 and 3 of repolarization; delayed afterdepolarizations follow full repolarization.
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In 6 out of 9 LQT1-iPSC-CMs early afterdepolarisation (EAD)--as a proarrhythmogenic predicate--could be triggered by treatment with isoproterenol.