African sleeping sickness


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African sleeping sickness

 

Gam·bi·an try·pan·o·so·mi·a·sis

a chronic disease of humans caused by Trypanosoma brucei gambiense in northern and sub-Saharan Africa from Senegal east to Sudan and Uganda; characterized by splenomegaly, drowsiness, an uncontrollable urge to sleep, and the development of psychotic changes; basal ganglia and cerebellar involvement commonly lead to chorea and athetosis; the terminal phase of the disease is characterized by wasting, anorexia, and emaciation that gradually leads to coma and death, usually from intercurrent infection.

African sleeping sickness

African sleeping sickness

African Trypanosomiasis

An infestation which cripples livestock and affects humans in sub-Saharan Africa; ±50 million Africans are at risk for this haematogenous parasitaemia.
Vector Tsetse fly.
Types
• Rhodesian trypanosomiasis, caused by Trypanosoma brucei rhodesiense, which is more common in East Africa.
• Gambian trypanosomiasis, caused by T brucei gambiense, which is more common in West Africa.
The trypanosome evades the host’s immune system by frequently changing the proteins on its outer surface, proteins by which the immune system identifies intruders.
Clinical findings Acute febrile syndrome, chills, headache, vomiting, pain in extremities, lymphadenopathy, anaemia, depression, fatigue, coma rapidly progressing to death; chronic disease with CNS depression. Sleeping sickness is more common in the West African form and eventually causes death if untreated.
Management Symptomatic (airway management, fever, malaise).
• East African trypanosomiasis Haematolymphatic stage: suramin; neurologic stage: melarsoprol.  
• West African trypanosomiasis  Haematolymphatic stage: pentamidine or suramin; neurologic stage: melarsoprol or eflornithine.

Gam·bi·an try·pa·no·so·mi·a·sis

(gam'bē-ăn trī-pan'ō-sō-mī'ă-sis)
A chronic disease of humans caused by Trypanosoma brucei gambiense in Africa; characterized by splenomegaly, drowsiness, an uncontrollable urge to sleep, and the development of psychotic changes; basal ganglia and cerebellar involvement commonly lead to chorea and athetosis; the terminal phase of the disease is characterized by wasting, anorexia, and emaciation that gradually lead to coma and death, usually from intercurrent infection.
Synonym(s): chronic trypanosomiasis.

Rho·de·sian try·pan·o·so·mi·a·sis

(rō-dē'zhŭn trī-pan'ō-sŏ-mī'ă-sis)
A disease of humans caused by Trypanosoma brucei rhodesiense in East Africa; it is clinically similar to Gambian trypanosomiasis but of shorter duration and more acute in form; patients suffer repeated episodes of pyrexia, become anemic, and commonly die from cardiac failure.
Synonym(s): acute African sleeping sickness, acute trypanosomiasis.

African sleeping sickness

See TRYPANOSOMIASIS.

African sleeping sickness

a fatal infection of the nervous and lymphatic systems that is endemic in certain parts of Africa and is caused by a flagellate protozoan called Trypanosoma, particularly T. brucei gambiense (West Africa) and T. bruceirhodesiense (East Africa). The vector of the flagellate is the tsetse fly Glossina, which also feeds on cattle, the latter acting as a reservoir for the parasite. African sleeping sickness is not to be confused with ENCEPHALITIS which is caused by a virus.

Patient discussion about African sleeping sickness

Q. Need Help.I could not enjoy the blessings of nature. I have sleep problem which affects me to a great extent. Hi friends, I need your help. I could not enjoy the blessings of nature. I have sleep problem which affects me to a great extent. Is there any remedy that I can try other than sleeping pills?

A. Many things can interfere with sleep ranging from anxiety to an unusual work schedule. But people who have difficulty in sleeping often discover that their daily routine holds the key to night-time woes.

? Cut down on caffeine.
? Stop smoking or chewing tobacco.
? Use alcohol cautiously
? Avoid a sedentary life
? Improve your sleep surroundings.
? Keep a regular schedule
? Keep a sleep diary
? Use strategic naps

If you try all the above suggestions and still have sleep problem, talk to your health-care provider.

More discussions about African sleeping sickness
References in periodicals archive ?
She is one of 5 patients reported to Eurosurveillance with East African sleeping sickness between 2005 and 2009[7].
In addition to trials for African sleeping sickness, pafuramidine is currently in Phase III clinical trials for PCP, and in Phase II trials targeting malaria treatment and malaria prophylaxis.
The research could contribute to new treatment strategies that are desperately needed to fight African sleeping sickness.
Existing treatments for African sleeping sickness that were developed over the past 80 years can cause severe side effects.
The 10GB winning project in Europe, led by Pascal Maser from the Swiss Tropical Institute (formerly University of Bern), together with Harry de Koning from the University of Glasgow, will use the sequencing award to uncover low-frequency genetic mutations in the parasite species Trypanosoma brucei subspecies which causes African sleeping sickness.
The company supports efforts to discover and advance novel treatments for neglected diseases such as malaria, Chagas disease and African sleeping sickness through its HAND initiative.
Scientists developed suramin in the 1920s as a treatment for African sleeping sickness.
He is also a member of the Board of the South South Initiative (SSI) of the World Health Organization Special Program for Research and Training in Tropical Diseases (WHO - TDR), and the coordinator in the field of Trypanosomiases, including Chagas Disease and African Sleeping Sickness.
SEATTLE -- Beginning today, Seattle Biomedical Research Institute (SBRI) is hosting a landmark international scientific conference, the 2004 TriTryp Genomes Meeting, which will bring together experts from around the world to discuss the first drafts of the genome sequences for three parasites that cause deadly infectious diseases including leishmaniasis, Chagas disease and African sleeping sickness.
Immtech's most promising compound, DB289, is currently in development for the treatment of malaria, pneumocystis carinii pneumonia (PCP), and African sleeping sickness.
The conference will feature a particular focus on parasitic protozoans that cause infectious diseases such as malaria, African sleeping sickness and leishmaniasis.
Similar to African sleeping sickness in humans, Surra causes wasting and death in animals around the world.

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