affinity maturation


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Affinity Maturation

The increased average affinity of antibodies to an antigen, which follows immunisation. Affinity maturation results from an increase of specific and more homogeneous IgG antibodies, and follows a less specific and more heterogeneous early response by IgM molecules.

affinity maturation

The mechanism during an immune response that produces antibodies with a strong ability to bind to a foreign antigen over time. Affinity maturation is produced by changes in the genes that encode immunoglobulin G (IgG) and by increased survival of those B lymphocytes that produce antibodies with the greatest ability to destroy a particular antigen. Increased affinity occurs only when B-cell activation is stimulated by helper T cells.
See also: maturation

affinity

1. attraction; a tendency to seek out or unite with another object or substance.
2. in chemistry, the tendency of two substances to form strong or weak chemical bonds forming molecules or complexes.
3. in immunology, the thermodynamic bond strength of an antigen-antibody complex.

antibody affinity
the strength of the binding interaction between antigen and antibody.
drug affinity
the attraction of a particular class of receptor to a drug, at a level sufficient to give an observable reaction. Such a drug is an agonist.
affinity maturation
the increased affinity of antibody for an antigen which occurs during the course of an immune response.
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References in periodicals archive ?
Because the recombinant IgE and IgG4 antibodies exhibit identical affinities due to their identical scFv moieties, the set of antibodies may mimic the circulating antibodies after affinity maturation of IgG antibodies that may occur after SIT.
AxioMx noted that it had received orders for more than USD 750,000 for custom services including antigen design, antibody discovery and development, and affinity maturation of existing antibodies during the last nine months.
Antibody Engineering: Humanization, Affinity Maturation, and Selection Techniques (Juan C.
Researchers at Xencor applied the company's proprietary humanization and affinity maturation technologies to decrease the immunogenicity of XmAb5574 and to increase both its affinity and stability.
The Platform, called ProCode, can be configured for monoclonal antibody selection, affinity maturation and library generation, for improving solubility and bioactivity of biopharmaceuticals, as well as identification and characterization of protein-protein interactions and discovery of protein drugs.