flunisolide

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flunisolide

 [floo-nis´o-līd]
a steroid antiinflammatory agent administered as an aerosol spray for treatment of bronchial asthma and seasonal or perennial allergic rhinitis when conventional treatment is unsatisfactory.

flunisolide

APO-Flunisolide (CA), Nasarel, PMS-Flunisolide (CA), Ratio-Flunisolide (CA), Rhinalar Nasal Mist (CA)

Pharmacologic class: Intranasal steroid

Therapeutic class: Respiratory inhalant

Pregnancy risk category C

Action

Unknown. Thought to diminish capillary permeability and suppress migration of polymorphonuclear leukocytes, decreasing inflammation.

Availability

Spray solution: 25 ml (each actuation delivers approximately 25 mcg)

Indications and dosages

Relief of seasonal or perennial rhinitis

Adults: Two sprays in each nostril b.i.d.; may increase to two sprays in each nostril t.i.d. Maximum daily dose is eight sprays in each nostril. For maintenance, after desired clinical effect occurs, reduce dosage to smallest amount needed to control symptoms.

Children ages 6 to 14: One spray in each nostril t.i.d. or two sprays in each nostril b.i.d.; maximum daily dose is four sprays in each nostril. For maintenance, after desired clinical effect occurs, reduce dosage to smallest amount needed to control symptoms.

Contraindications

• Hypersensitivity to drug or its components

• Untreated local infections of nasal mucosa

Precautions

Use cautiously in:

• localized Candida albicans infection; tuberculosis; untreated fungal, bacterial, or systemic viral infections; ocular herpes simplex

• patients receiving immunosuppressive therapy.

Administration

• Don't increase dosage or discontinue drug abruptly.

Adverse reactions

CNS: headache, light-headedness, nervousness, dizziness

EENT: cataracts; glaucoma; blurred vision; conjunctivitis; increased intraocular pressure; lacrimation; dry, irritated eyes; tinnitus; otitis; otitis media; rhinorrhea; rhinitis; nasal irritation, burning, and dryness; nasal stuffiness and pain; sneezing; nasal ulcer; epistaxis; localized Candida albicans nasal infections; nasal mucosa ulcerations; nasal septum perforation; throat discomfort, soreness, and dryness; mild nasopharyngeal irritation; pharyngitis; dry mucous membranes; nasal and sinus congestion; sinusitis; hoarseness, voice changes

GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia, dry mouth

Metabolic: hyperadrenocorticism

Musculoskeletal: myalgia, arthralgia, aseptic necrosis of femoral head

Respiratory: wheezing, dyspnea, increased cough, bronchitis, bronchospasm, asthma symptoms

Skin: rash, pruritus, urticaria, contact dermatitis, alopecia, herpes simplex infection

Other: altered taste and smell, facial edema, fever, flulike symptoms, aches and pains, infections, angioedema, anaphylaxis

Interactions

Drug-diagnostic tests. Aspartate aminotransferase: increased level

Patient monitoring

Monitor patient closely for serious adverse reactions, including anaphylaxis, angioedema, hyperadrenocorticism, and serious infections.

Patient teaching

Teach patient to recognize and immediately report serious adverse reactions.

• Teach patient proper use of drug. Caution him not to use more than prescribed amount; doing so may cause serious side effects.

• Tell patient maximum drug effects may not occur for several weeks.

• Tell patient to avoid people with measles, chickenpox, and other transmissible infections.

• Caution patient to withhold dose and contact prescriber if infection occurs.

• Instruct female patient to tell prescriber if she becomes pregnant.

• Tell female patient not to breastfeed without consulting prescriber.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the tests mentioned above.

flunisolide

(flo͞o-nĭs′ə-līd′)
n.
A corticosteroid, C24H31FO6, administered by inhalation to treat asthma and nasally to treat allergies.

flunisolide

Aerobid® An inhalant corticosteroid used to manage asthma

flunisolide

A CORTICOSTEROID drug used in the form of a spray to treat hay fever. A brand name is Syntaris.
References in periodicals archive ?
The Aerospan product, which has a built-in inhalation chamber called spacer, has already been approved by the US Food and Drug Administration (FDA) and is expected to be introduced early next year.Country: USASector: PharmaceuticalsTarget: Acton Pharmaceuticals IncBuyer: Meda ABDeal size in USD: 145mType: Corporate acquisitionFinancing: Existing resources, DebtStatus: Closed
Aerospan (flunisolide HFA, 80 mcg) is approved by the US Food and Drug Administration (FDA) for the treatment of asthma in adult and paediatric patients 6 years of age and older.
* Special Considerations: Monitor asthma patients closely if they transfer from systemically active corticosteroids to Aerospan inhalation aerosol; deaths from adrenal insufficiency have been reported when patients switch from systemic corticosteroids to less systemically available inhaled corticosteroids.
Another exchange that was scheduled to beign operations in the summer of 2000 is Aerospan.com an e-business site for the aviation transportation industry.
Allow them to use sites like buy.com, myaircraft.com, Exostar.com, aerospan.com, and others to buy authorized items and services.
A joint venture between SITA and AAR called aerospan.com will be launched in the middle of this year that will enable airlines to source, buy and sell products and services online.
M2 PHARMA-September 21, 2012-Acton Pharmaceuticals Inc wins US FDA approval for AEROSPAN Inhalation Aerosol for asthma(C)2012 M2 COMMUNICATIONS
has received Food and Drug Administration approval to sell its inhaled asthma treatment Aerospan.
Flunisolide (AeroBid, Aerospan) is another topically active aerosol preparation, similar in potency to triamcinolone, and is said to have a longer duration of action.
Aerospan (flunisolide HFA, 80-mcg inhalation aerosol, Forest Laboratories Inc.)
The new company, which will be called aerospan.com, will be equally owned by SITA and AAR and have its headquarters in Chicago.

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