"All you have to do is open, inhale, and then close it; there is nothing else the patient has to do." There is no active aerosolisation engine; instead, the aerosolization is produced by the patient breathing--a primary design challenge, according to Allen.
The American Nephrology Nurses Association Core Curriculum for Nephrology Nursing recommendations require staff to wear protective eyewear and a mask if there is a possibility of splashes, spray, splatter, or aerosolisation of blood into the eyes, mouth or any mucous membrane (Lancaster, 2001).
Dental staff can also be exposed to latex aeroallergens from powdered dental rubber dams that are usually stretched when used during dental procedures, so increasing the aerosolisation of NRL particles.
Recombinant pneumolysin aerosolisation or infusion into the lung caused significant vascular leakage and pulmonary oedema, and pneumolysin infusion into the pulmonary circulation induced pulmonary hypertension, both these manifestations being important features of acute respiratory distress syndrome.