adverse drug event

(redirected from Adverse Drug Events)
Also found in: Acronyms.

adverse drug event

(ad-vĕrs drug ĕ-vent'),
"an injury resulting from medical intervention related to a drug." [Institute of Medicine]
See also: adverse event.

adverse drug reaction

Any noxious and unintended response associated with the use of a drug in humans.

Adverse Drug Reaction

Any noxious, undesired, or unintended response to a therapeutic agent, which may be expected or unexpected, and may occur at dosages used for the prophylaxis, diagnosis, or therapy of disease, or for modifying physiologic function. ADRs do not include therapeutic failures, poisoning, accidental or intentional overdoses. ADRs occur in up to 15% of all drug administrations, but are rarely fatal. They can be divided into type A—dose-dependent or predictable—or type B—idiosyncratic or allergic—reactions.
Clinical findings Pruritus, nausea, vomiting, rash, confusion, lethargy, etc.
Culprits ADR are most commonly caused by analgesics and narcotics, antibiotics, cardiovascular agents, anticoagulants, and psychotherapeutics.
Regulatory process In the preapproval clinical experience with a new medicinal product or its new usages, particularly as the therapeutic dose(s) may not be established, all noxious and unintended responses to a medicinal product related to any dose should be considered adverse drug reactions; a causal relationship between a medicinal product and an adverse event is at least a reasonable possibility—i.e., the relationship cannot be ruled out.
References in periodicals archive ?
In "Incidence and Preventability of Adverse Drug Events Among Older Persons in the Ambulatory Setting," Jerry Gurwitz of the University of Massachusetts Medical School and his colleagues conclude that problems are common and that many of them can be prevented.
The study is using CDISC's Retrieve Form for Data Capture (RFD) standard to automatically recognize adverse drug events recorded in the Longitudinal Medical Record (LMR), an electronic health record system currently in use at Brigham and Women's Hospital and Massachusetts General Hospital, founding members of Partners HealthCare.
In this special report, "Medication Reconciliation Strategies to Reduce Hospital Adverse Drug Events," Donna Isgett, McLeod vice president for clinical effectiveness, describes the hospital's emphasis on quality and perfect care processes, while Leanne Huminski, chief nursing officer, provides the inside details on McLeod's medication management program, which has a goal of eliminating adverse drug events.
Hanlon found that one-third of the patients had an adverse drug event, and most of those events occurred within 3 months of the hospitalization.
Sermo provides a new way to gather information on adverse drug events that differs from traditional event reporting systems in two important ways: 1) on Sermo, physicians are given multiple incentives to submit information, and 2) Sermo uses the physician community itself to determine what is important, rather than relying on a small group of researchers to review massive amounts of information.
Humana's Medication Therapy Management (MTM) program provides pharmacists with a suite of medication review solutions and clinical measures to identify problems or gaps in prescription drug therapy and better assist Medicare beneficiaries reduce the risk of over or under utilization of medications, promote adherence and decrease the likelihood of adverse drug events.
Together with its development partners, First DataBank helps reduce the incidence of medication errors and adverse drug events, which promises to lower healthcare costs and improve patient care.
Further, the Center for Information Technology Leadership estimates that more than 2 million adverse drug events annually and nationally could be prevented through electronic prescribing.
KatrinaHealth fundamentally changed the way patient medical information is utilized in disaster relief efforts by establishing a blueprint that will enable a faster, more efficient response to future disasters, preventing disruptions in medication use, potential prescription errors and adverse drug events," said Medvedeff.
To report suspected adverse drug events for Osurnia, contact Elanco US Inc.
Synowledge specializes in pharmacovigilance, regulatory affairs and information technology services to support biopharma companies with recording, analyzing and reporting adverse drug events.
As part of an update in September 2014 to the ONC Health IT Safety Program--Progress on Health IT Patient Safety Action and Surveillance Plan, the agency noted that a study published in the summer of 2014 funded by HHS' Agency for Healthcare Research and Quality (AHRQ) found that Florida hospitals that adopted all five core measures of Meaningful Use for medication management in 2010 had the lowest rate of adverse drug events of all hospitals in the state.