adverse drug event

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adverse drug event

(ad-vĕrs drug ĕ-vent'),
"an injury resulting from medical intervention related to a drug." [Institute of Medicine]
See also: adverse event.

adverse drug reaction

Any noxious and unintended response associated with the use of a drug in humans.

Adverse Drug Reaction

Any noxious, undesired, or unintended response to a therapeutic agent, which may be expected or unexpected, and may occur at dosages used for the prophylaxis, diagnosis, or therapy of disease, or for modifying physiologic function. ADRs do not include therapeutic failures, poisoning, accidental or intentional overdoses. ADRs occur in up to 15% of all drug administrations, but are rarely fatal. They can be divided into type A—dose-dependent or predictable—or type B—idiosyncratic or allergic—reactions.
Clinical findings Pruritus, nausea, vomiting, rash, confusion, lethargy, etc.
Culprits ADR are most commonly caused by analgesics and narcotics, antibiotics, cardiovascular agents, anticoagulants, and psychotherapeutics.
Regulatory process In the preapproval clinical experience with a new medicinal product or its new usages, particularly as the therapeutic dose(s) may not be established, all noxious and unintended responses to a medicinal product related to any dose should be considered adverse drug reactions; a causal relationship between a medicinal product and an adverse event is at least a reasonable possibility—i.e., the relationship cannot be ruled out.
References in periodicals archive ?
The CVM has created a database --the Cumulative Adverse Drug Event Summaries Report--"so that veterinarians and animal owners can have easily available access to information about signs that have been associated with drugs." That database can be accessed here:tinyurl.com/cumulativeADEs.
Impact of medication reconciliation and review and counselling, on adverse drug events and healthcare resource use.
CMS recently initiated "Medication Adverse Drug Event" focus surveys noting that one in three SNF residents is harmed by an adverse event or temporary harm event within the first 35 days of a SNF stay, and 37 percent of those adverse events are related to medication.
On the other hand, the market, by services, is segmented into medication analytics, point-of-care verification, and ADE (adverse drug events) surveillance services offered by medication management solutions vendors.
In an analysis of data from a nationally representative sample of hospitals in the National Electronic Injury Surveillance System-Cooperative Adverse Drug Event Surveillance project, researchers estimated that 97,648 ED visits occurred annually during a 5-year period among adults with type 2 diabetes who presented with hypoglycemia-related shock, loss of consciousness, seizure, injury or fall, or altered mental status.
According to the studs children under age 2 previously accounted for 4.1% of all emergency room visits for adverse drug events; after the moves they accounted for 2.4% of such visits.
He also showed medication errors related to Beta Blockers and Aspirin at admission and discharge in various hospitals and highlighted the roadmap to medication safety as regards adverse drug events. While use of Low Dose Aspirin daily offers many benefits as regards cardiovascular diseases but it also has some risks.
Identifying hospital admissions due to adverse drug events using a computer-based monitor.
A thorough literature search was conducted using PubMed and Google Scholar to select articles from 2000 till 2012 using key words like polypharmacy, geriatric patients, elderly care, Beer's criteria, inappropriate prescribing and adverse drug events. Key phrases like "oral hypoglycaemic drugs and elderly" were also used to search articles for specific drugs.
Thirty percent of patients had one or more adverse drug events that were considered to be preventable or ameliorable.
Given that much of the variation in drug response can be attributed to genetic differences, tailoring drugs to an individual's unique genetic signature provides the opportunity to reduce adverse drug events, improve drug efficacy, optimize trial design, and prevent costly drug recalls (1).