Advanced Glycosylation Endproduct

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Advanced Glycosylation Endproduct

Any glycoprotein derived from the hyperglycaemia-induced Amadori reaction, which causes some of the complications of diabetes—e.g., vasculopathy (leakage of proteins across vessels and progressive stenosis) of small and large vessels, atherosclerosis, cataracts and nephropathy. In diabetes, hyperglycaemia causes proteins to combine with glycosylation endproducts in a reversible—early glycosylation endproducts—or irreversible fashion. Haemoglobin A1c (HbA1c) is an AGE formed during hyperglycaemia; levels of < 7% (IFCC-HbA1c of < 50 mmol/mol) correlate well with euglycaemia in diabetics. HbA1c is a useful tool for managing diabetics as poor control is recognised earlier and managed more aggressively.
References in periodicals archive ?
Maramaldi noted the skin is particularly vulnerable to "the glycation mechanism, a reaction occurring when a sugar like glucose or fructose and proteins, lipids, or DNA interact non-enzymatically, leading to the production of glycotoxins (Advanced Glycation Endproduct, AGEs, and Advanced Lipoxidation Endproducts, ALEs).
Gerrits, "Skin autofluorescence as a measure of advanced glycation endproduct deposition: a novel risk marker in chronic kidney disease," Current Opinion in Nephrology and Hypertension, vol.
Kawamori, Effect of Metformin on Advanced Glycation Endproduct Formation and Peripheral Nerve Function in Streptozotocin- Induced Diabetic Rats, Europ J.
Simple non-invasive assessment of advanced glycation endproduct accumulation.
Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice.
Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension.
Advanced glycation endproduct crosslinking in the cardiovascular system: potential therapeutic target for cardiovascular disease.
MG is a type of advanced glycation endproduct (AGEs), which is produced when food is cooked with dry heat.
Isolation and characterization of a new advanced glycation endproduct of dehydroascorbic acid and lysine.
BACKGROUND: Advanced glycation endproduct (AGE) formation is thought to contribute to aging and cataract formation in the lens.
Oomen et al., "Simple noninvasive assessment of advanced glycation endproduct accumulation," Diabetologia, vol.
Abbreviations A1C: Glycated haemoglobin AGE: Advanced glycation endproduct CEdG and N2-(1,R/S-Carboxyethyl) CEd[G.sub.A]/CEd[G.sub.B]: deoxyguanosine and R/S epimers dG: Deoxyguanosine GdG: 3-(2'-Deoxyribosyl)-6,7-dihydro-6,7- dihydroxyimidazo-[2,3-b]purin-9(8)one eGFR: Estimated glomerular filtration rate Glo1: Glyoxalase 1 8-OxodG: 7,8-Dihydro-8-oxo-2'-deoxyguanosine 4HNE: 4-Hydroxynonenal MGdG: 3-(2'-Deoxyribosyl)-6,7-dihydro-6,7- dihydroxy-6/7-methylimidazo-[2,3- b]purine-9(8)one LC-MS/MS: Liquid chromatography with tandem mass spectrometric detection UAE: Urinary albumin excretion DN: Diabetic nephropathy.

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