advanced glycation endproducts

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advanced glycation endproducts

; AGEs formation of endproducts of non-enzymatic protein lipoproteins and nucleic acid glycosylation; exaggerated in old age, but accelerated in poorly controlled diabetes mellitus; AGEs accumulate in structural proteins (of ligaments, blood vessel walls, etc.) to compromise the microcirculation, especially within skin, vasa vasorum and vasa nervosum, contributing to the secondary complications of long-term diabetes, i.e. loss of joint mobility, neuropathy and ischaemia (see glycosylated haemoglobin; glycosylation)
References in periodicals archive ?
BACKGROUND: Advanced glycation endproduct (AGE) formation is thought to contribute to aging and cataract formation in the lens.
Kawamori, Effect of Metformin on Advanced Glycation Endproduct Formation and Peripheral Nerve Function in Streptozotocin- Induced Diabetic Rats, Europ J.
Simple non-invasive assessment of advanced glycation endproduct accumulation.
Effect of metformin on advanced glycation endproduct formation and peripheral nerve function in streptozotocin-induced diabetic rats," European Journal of Pharmacology, vol.
Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice.
Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension.
Advanced glycation endproduct crosslinking in the cardiovascular system: potential therapeutic target for cardiovascular disease.
MG is a type of advanced glycation endproduct (AGEs), which is produced when food is cooked with dry heat.
Isolation and characterization of a new advanced glycation endproduct of dehydroascorbic acid and lysine.
Body weight, blood glucose, endothelium-dependent/-independent relaxation, vasocontraction by free radical-induced and contractive prostanoids, triglyceride, advanced glycation endproduct, lipid peroxides, serum N[O.
The advanced glycation endproduct CIVIL is a product both of lipid peroxidation and glycoxidation reactions J Biol Chem 1996;271:9982-6.

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