Chemotherapy for advanced gastric cancer
. Cochrane Database Syst Rev 2010; 17: CD004064.
To the best of our knowledge, few studies of ERAS focus on patients with locally advanced gastric cancer
who are administered neoadjuvant chemotherapy.
Wang et al., "Does a higher cutoff value of lymph node retrieval substantially improve survival in patients with advanced gastric cancer
?--Time to embrace a new digit," The Oncologist, vol.
e, "HER2-positive advanced gastric cancer
:similar HER2-positivity levels to breast cancer," European Journal of Cancer, vol.
In conclusion, some progress has been reached in the treatment of advanced gastric cancer
in the last years.
Hejna, "Palliative chemotherapy for advanced gastric cancer
," Annals of Oncology, vol.
The prognostic significance of HER2 positivity for advanced gastric cancer
patients undergoing first-line modified FOLFOX-6 regimen.
Laura added: "Immunotherapy is available here on the NHS but has only been approved for certain cancers and has not been approved for stomach cancer, despite evidence showing it has the potential to increase life expectancy dramatically in advanced gastric cancer
compared to chemotherapy.
However, even after potentially curative resection with satisfactory safety margins, the prognosis of patients with locally advanced gastric cancer
is still worrying.
The Japanese Gastric Cancer Association (7) recommended simultaneous splenectomy during total gastrectomy to facilitate removal of splenic hilar lymph nodes in advanced gastric cancer
involving the upper third of the stomach.
These two trials emphasize the efficacy of preoperative chemotherapy in advanced gastric cancer
, suggesting a new direction in the treatment of AGC.
Combinations of surgery, chemotherapy, and radiotherapy are common treatment options for advanced gastric cancer
, but the prognosis is always poor [4, 5].